581065-50-1

Upstream product

• 13246-46-3 2,4-dibenzyloxybenzaldehyde 
• 581065-47-6 N,N-dimethyl 2-(2,4-dibenzyloxyphenyl)-2-hydroxyethanethioamide 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 1026250-38-3 (4,6-bis-benzyloxy-benzo[b]thiophen-2-yl)-dimethyl-amine 

Downstream Products

• 581065-64-7 N,N-diethyl 6-(benzyloxy)-2-[4-(benzyloxy)phenyl]-4-hydroxybenzo[b]thiophene-3-carboxamide 
• 581065-54-5 N,N-diethyl 4,6-dibenzyloxy-2-(4-benzyloxyphenyl)benzo[b]thiophene-3-carboxamide 
• 581065-65-8 6-(benzyloxy)-2-[4-(benzyloxy)phenyl]-3-[(diethylamino)carbonyl]benzo[b]thiophen-4-yl trifluoromethanesulfonate 
• 581065-66-9 N,N-diethyl 6-(benzyloxy)-2-[4-(benzyloxy)phenyl]-4-[3-(2-piperidinoethoxy)phenyl]benzo[b]thiophene-3-carboxamide 
• 581065-68-1 7-(2-piperidinoethoxy)-2-[(1,1,1-tri-iso-propylsilyl)oxy]-5-[4-(1,1,1-tri-iso-propylsilyloxy)phenyl]-6H-phenanthro[1,10-bc]thiophen-6-one 
• 581065-67-0 N,N-diethyl 4-[3-(2-piperidinoethoxy)phenyl]-6-[(1,1,1-tri-iso-propylsilyl)oxy]-2-[4-(1,1,1-tri-iso-propylsilyloxy)phenyl]benzo[b]thiophene-3-carboxamide 

Relevant academic research and scientific papers

Synthesis of constrained raloxifene analogues by complementary use of Friedel-Crafts and directed remote metalation reactions

New constrained heterocyclic analogues, 2a,b and 3, of Raloxifene (1) have been prepared by complementary Directed remote Metalation (DreM)/Friedel-Crafts cyclization approaches. Utilization of a benzylidene-thiolactone rearrangement was successfully impl