581065-52-3Relevant academic research and scientific papers
Synthesis of constrained raloxifene analogues by complementary use of Friedel-Crafts and directed remote metalation reactions
Kalinin, Alexey V.,Reed, Mark A.,Norman, Bryan H.,Snieckus, Victor
, p. 5992 - 5999 (2007/10/03)
New constrained heterocyclic analogues, 2a,b and 3, of Raloxifene (1) have been prepared by complementary Directed remote Metalation (DreM)/Friedel-Crafts cyclization approaches. Utilization of a benzylidene-thiolactone rearrangement was successfully impl
