58107-54-3Relevant articles and documents
ENZYME-CATALYZED ENANTIOSELECTIVE AZIRIDINATION OF OLEFINS
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Paragraph 0195-0198, (2016/08/29)
The present invention provides methods for catalyzing the conversion of an olefin to a compound containing one or more aziridine functional groups using heme enzymes. In certain aspects, the present invention provides a reaction mixture for producing an aziridination product, the reaction mixture comprising of an olefinic substrate, a nitrene precursor, and a heme enzyme. In other certain aspects, the present invention provides a method for producing an aziridination product comprising providing an olefinic substrate, a nitrene precursor, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce an aziridine product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin aziridination reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention.
Regiospecific Intermolecular Aminohydroxylation of Olefins by Photoredox Catalysis
Miyazawa, Kazuki,Koike, Takashi,Akita, Munetaka
, p. 11677 - 11680 (2015/08/11)
A simple and regiospecific aminohydroxylation of olefins by photoredox catalysis has been developed. N-protected 1-aminopyridinium salts are the key compounds and serve as amidyl radical precursors by the action of Ir photocatalysts, fac-[Ir(ppy)3/s
Ring-opening reaction of aziridines using aqueous polyacrylamide (PAM) as the reaction medium
Wang, Yan,Zhang, Ming Jie,Zhu, Jie,Li, Zhong Bo
experimental part, p. 1367 - 1370 (2012/04/10)
A novel efficient method for the hydrolysis of aziridines using aqueous Polyacrylamide (PAM) is described. An aqueous PAM solution serves as the reagent, the catalyst and the reaction medium. The reaction is fast (30 min), operationally simple, regiosclec