58122-05-7Relevant academic research and scientific papers
Visible-Light-Promoted Alkylation of Indoles with Tertiary Amines by the Oxidation of a sp3 C-H Bond
Ding, Xuan,Dong, Chun-Lin,Guan, Zhi,He, Yan-Hong
, p. 762 - 767 (2017/12/26)
A visible-light driven reaction for the synthesis of 3-arylmethyl indole derivatives using tertiary amines and indoles was first reported. Corresponding products were obtained with yields of up to 70%, and various functional groups on the indoles were well tolerated when Rose Bengal was used as a photosensitizer and air was used as a green oxidant under mild reaction conditions. (Figure presented.).
Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water
Kumar, Atul,Kumar, Mukesh,Gupta, Maneesh Kumar
supporting information, p. 2677 - 2681,5 (2020/09/14)
We report the first C-H hydroarylation of in situ generated ortho-quinone methides with electron-rich arenes. The reaction takes place in water without any catalyst, and is highly regioselective. Ionic and non-ionic additives provide an increase in reaction rate, yield, and regioselectivity.
Electrophilic ipso-Substitutions. Part 2. Reactions of 3-Substituted Indoles and 4-Substituted NN-Dimethylanilines with Arenediazonium Ions
Colonna, Martino,Greci, Lucedio,Poloni, Marino
, p. 455 - 460 (2007/10/02)
3-Substituted indoles and 4-substituted NN-dimethylanilines react with arenediazonium ions to form 3-arylazo-indoles and 4-arylazo-NN-dimethylanilines, respectively.The formation of the ?-complex intermediate was interpreted both as electrophilic ipso-attack and as coupling of two radicals deriving from an electron transfer process.Both mechanisms are discussed on the basis of the experimental evidence and on the substrate oxidation potentials.The leaving abilities of the substituents are discussed on the basis of the experimental results.
