58138-74-2

Basic information

• Product Name: 2-HYDROXY-3,4-DIMETHYL-BENZOIC ACID
• Synonyms: 2-HYDROXY-3,4-DIMETHYL-BENZOIC ACID;3,4-Dimethyl-2-hydroxybenzoic acid
• CAS NO: 58138-74-2
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.18
• Mol File: 58138-74-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 323.5°Cat760mmHg
• Flash Point: 163.7°C
• Appearance: /
• Density: 1.249g/cm³
• Vapor Pressure: 0.000107mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 2-HYDROXY-3,4-DIMETHYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-3,4-DIMETHYL-BENZOIC ACID(58138-74-2)
• EPA Substance Registry System: 2-HYDROXY-3,4-DIMETHYL-BENZOIC ACID(58138-74-2)

Safety Data

• Hazardous Substances Data: 58138-74-2(Hazardous Substances Data)

Usage

Uses

2-Hydroxy-3,4-dimethylbenzoic Acid is a useful reagent used in the synthesis of tumor vascular disrupting agent vadimezan.

InChI:InChI=1/C9H10O3/c1-5-3-4-7(9(11)12)8(10)6(5)2/h3-4,10H,1-2H3,(H,11,12)

Upstream product

• 71321-28-3 2-Hydroxy-2-(2-hydroxy-3,4-dimethyl-phenyl)-indan-1,3-dione 
• 526-75-0 2,3-Dimethylphenol 
• 619-04-5 3,4-dimethylbenzoic acid 
• 124-38-9 carbon dioxide 
• 95646-20-1 3-(2-Hydroxy-3,4-dimethyl-benzoyl)-2-p-tolyl-2,3-dihydro-isoindol-1-one 

Downstream Products

• 91061-57-3 methyl 2-hydroxy-3,4-dimethylbenzoate 

Relevant articles and documents

Carboxylation of Phenols with CO2 at Atmospheric Pressure

A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO2. The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.

A new and mild synthesis of substituted salicylic acids

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