58144-71-1

Upstream product

• 4937-87-5 N-hydroxy-2-oxo-2-phenylethanimidoyl chloride 
• 1777-59-9 1-(naphthalen-2-yl)-2-(triphenylphosphoranylidene)ethanone 

Relevant academic research and scientific papers

Facile synthesis of disubstituted isoxazoles from homopropargylic alcohol via C=N bond formation

A novel iron-catalyzed aerobic oxidative reaction to synthesize disubstituted isoxazoles from homopropargylic alcohol, t-BuONO, and H2O is developed. The method provides mild conditions to afford a variety of useful substituted heterocycles in an efficient and regioselective manner. The mechanism has been studied and proposed, which indicates that the transformation can be realized through construction of a C=N bond and C=O bond, C-H oxidation, and then cyclization. Moreover, this method can be enlarged to gram scale.