58153-99-4

Basic information

• Product Name: 1-Propanone, 3-[(4-chlorophenyl)amino]-1-phenyl-
• CAS NO: 58153-99-4
• Molecular Formula: C15H14ClNO
• Molecular Weight: 259.735
• Mol File: 58153-99-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 3-[(4-chlorophenyl)amino]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-[(4-chlorophenyl)amino]-1-phenyl-(58153-99-4)
• EPA Substance Registry System: 1-Propanone, 3-[(4-chlorophenyl)amino]-1-phenyl-(58153-99-4)

Safety Data

• Hazardous Substances Data: 58153-99-4(Hazardous Substances Data)

Upstream product

• 5409-66-5 3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine 
• 106-47-8 4-chloro-aniline 
• 3506-36-3 3-dimethylaminopropiophenone 
• 93-55-0 1-phenyl-propan-1-one 
• 71-43-2 benzene 
• 936-59-4 3-chloropropiophenone 
• 5650-41-9 3-hydroxy-1-phenylpropan-1-one 
• 768-03-6 Phenyl vinyl ketone 
• 2298-49-9 N-methyl-3-oxo-N-(3-oxo-3-phenylpropyl)-3-phenylpropan-1-aminium chloride 
• 7661-27-0 N-(4'-chlorophenyl)-2-azetidinone 
• 50-00-0 formaldehyd 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 76369-26-1 (Z)-3-(4-Chloro-phenylamino)-3-methylsulfanyl-1-phenyl-propenone 

Downstream Products

• 1325232-95-8 3,4,5,6-tetrahydro-4-(p-chlorophenyl)-2-(p-nitrophenyl)-7-phenyl-2H-1,2,4-triazepine 
• 1048974-42-0 1-(4-methoxyphenyl)-3-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1048974-41-9 1-(4-methylphenyl)-3-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1048974-40-8 1,3-bis(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 1048974-43-1 1-(3,4,5-trimethoxyphenyl)-3-(4-chlorophenyl)-6-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 89410-09-3 2-Aziridin-1-yl-3-(4-chloro-phenyl)-6-phenyl-[1,3,2]oxazaphosphinane 2-oxide 
• 89410-03-7 2-Chloro-3-(4-chloro-phenyl)-6-phenyl-[1,3,2]oxazaphosphinane 2-oxide 
• 15145-57-0 1-Phenyl-3-(p-chlor-anilino)-propanol-⁽¹⁾ 

Relevant articles and documents

Synthesis of 3-aroyl-4-hydroxy-4-arylpiperidine derivatives by DBU-catalyzed reactions of amines with vinyl ketones

In one-pot cascade reaction, a series of functionalized 3-aroyl-4-hydroxy-4-arylpiperidine derivatives were prepared from sulfonamides and vinyl ketones with good to excellent yields and diastereoselectivities. The reaction was catalyzed by the commercially available Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and could be easily manipulated under mild condition. Georg Thieme Verlag Stuttgart · New York.

Iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to form β-aminoketones and Benzo[h]quinolones

An iodine-catalyzed coupling of β-hydroxyketones with aromatic amines to yield β-aminoketones and benzo[h]quinolones had been developed. Noble metallic catalysts, oxidants, α β-unsaturated ketone intermediates and aza-Michael addition were not involved in this coupling reaction which made it unique when compared to other reactions reported in literature. Inexpensive iodine catalyst, easy accessible raw materials, mild reaction conditions, good functional group tolerance and excellent selectivity made this coupling reaction be a practical method. This reaction can also be scaled up.

Aza-Michael reaction promoted by aqueous sodium carbonate solution

A general and efficient aza-Michael reaction promoted by aqueous sodium carbonate solution has been developed. The reaction has complete mono-alkylation selectivity and proceeds with complete chirality retention for chiral amino esters. With a broad substrate scope, a well-common catalyst and simple operation, the catalytic approach provides a facile, practicable, economical, and environmentally benign method for the synthesis of β-amino carbonyl compounds.