5817-09-4Relevant academic research and scientific papers
Aceglutamide and its injection and preparation method
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Paragraph 0050-0061, (2018/04/26)
The invention relates to the field of medicinal preparation, and provides aceglutamide, a preparation method thereof, an aceglutamide injection and a preparation method for the injection. According to the preparation of the aceglutamide, acetic anhydride is replaced by acetyl chloride, so that the reaction speed is accelerated, the time is shortened, the yield is greatly improved, and the yield reaches over 95 percent. During the preparation process of the compound provided by the invention, activated carbon is not required to be added; absorption loss is reduced; the treating process is simplified; the cost is reduced; the obtained compound is a new crystal; the clinical application effect is more ideal. Meanwhile, specific improvement is made for the preparation method for the aceglutamide injection, the conventional preparation method from thick preparation to diluted preparation is changed into one-step preparation, so that material preparation process is simplified; the preparation time is shortened; the temperature of the water used for preparing the injection is controlled, so that the levels of related materials of a product are effectively controlled. The preparation with higher quality can be obtained, and the medication safety of a patient is ensured.
