58185-48-1

Upstream product

• 771-99-3 4-phenylpiperidine 
• 106-96-7 propargyl bromide 

Downstream Products

• 501031-08-9 (S)-3-{4-[3-(4-Phenyl-piperidin-1-yl)-prop-1-ynyl]-phenyl}-2-pyrrol-1-yl-propionic acid methyl ester 
• 1017241-16-5 1-(2,2-difluoropropyl)-4-phenyl-piperidine 
• 1039487-32-5 1-((3-phenethyl-3H-1,2,3-triazol-4-yl)methyl)-4-phenylpiperidine 
• 1234358-19-0 C₂₄H₃₄N₄O₃ 
• 1234358-56-5 C₂₀H₃₀N₄O 
• 1234358-10-1 C₂₄H₂₈N₄O₃ 
• 1247135-65-4 6-methoxy-2-methyl-4-(4-[(4-phenylpiperidin-1-yl)methyl]-1H-1,2,3-triazol-1-yl)quinoline 

Relevant academic research and scientific papers

Library of 1,4-disubstituted 1,2,3-triazole analogs of oxazolidinone RNA-binding agents

The design and synthesis of small molecules that target RNA is immensely important in antibacterial therapy. We had previously reported on the RNA binding of a series of 4,5-disubstituted 2-oxazolidinones that bind to a highly conserved bulge region of bacterial RNA. This biological target T box antitermination system, which is found mainly in Gram-positive bacteria, regulates the expression of several amino acid related genes. In an effort to amplify our library, we have prepared a library of 1,4-disubstituted 1,2,3-triazole analogs that entails an isosteric replacement of the oxazolidinone nucleus. The synthesis of the new analogs was enhanced via copper(I) catalysis of an azide and alkyne cycloaddition reaction. A total of 108 1,4-disubstituted 1,2,3-triazole compounds have been prepared. All compounds were evaluated as RNA binding agents.

4 ( 1H) -PYRIDINONE DERIVATIVES AND THEIR USE AS ANTIMALARIA AGENTS

4-pyridone (4-pyridinone) derivatives of Formula (I) and pharmaceutically acceptable derivatives thereof, processes for their preparation, pharmaceutical formulations thereof and their use in chemotherapy of certain parasitic infections such as malaria, are provided.

Design, synthesis and antimicrobial activities of some new quinoline derivatives carrying 1,2,3-triazole moiety

A new series of [1-(6-methoxy-2-methylquinolin-4-yl)-1H-1,2,3-triazol-4-yl] methanamine derivatives were synthesized starting from 4-methoxyaniline through multi-step reactions. The title compounds 5a-y were prepared by treating the azide intermediate 4 with propargyl bromide and different alkyl/heterocyclic amines in a sequential three component synthesis. All the new compounds were characterized by spectral and elemental analyses. The newly synthesized final compounds were evaluated for their in vitro antibacterial and antifungal activities against pathogenic strains. The preliminary screening results indicated that most of the compounds demonstrated moderate to very good antibacterial and antifungal activities, comparable to the first-line drugs. Twenty five new derivatives of [1-(6-methoxy-2-methylquinolin-4-yl)-1H-1,2,3- triazol-4-yl] methanamine have been synthesized and the most effective compounds have MIC of 6.25 μg/mL, which are in comparable with present antibiotics.

Natural products in parallel synthesis: Triazole libraries of nonactic acid

The synthesis of a library of nonactic acid-derived triazoloamide derivatives and their evaluation as antimicrobial agents is described.