58196-33-1

Basic information

• Product Name: 7-Hydroxy-1,2,3,4-tetrahydroquinoline
• Synonyms: 7-Hydroxy-1,2,3,4-Tetrahydro Quinolinoe;7-Hydroxy-1,2,3,4-tetrahydroquinoline;7-hydroxy-1,2,3,4-Tetrahydro-quinolin;1,2,3,4-Tetrahydro-quinolin-7-ol;1,2,3,4-Tetrahydro-7-quinolinol;7-Quinolinol, 1,2,3,4-tetrahydro-
• CAS NO: 58196-33-1
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.19
• EINECS: -0
• Mol File: 58196-33-1.mol
• Article Data: 30

Chemical Properties

• Melting Point: 70-80 °C
• Boiling Point: 319.7 °C at 760 mmHg
• Flash Point: 174.7 °C
• Appearance: /
• Density: 1.141 g/cm₃
• Vapor Pressure: 0.000611mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 10.70±0.20(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: 7-Hydroxy-1,2,3,4-tetrahydroquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxy-1,2,3,4-tetrahydroquinoline(58196-33-1)
• EPA Substance Registry System: 7-Hydroxy-1,2,3,4-tetrahydroquinoline(58196-33-1)

Safety Data

• Hazardous Substances Data: 58196-33-1(Hazardous Substances Data)

Usage

General Description

7-Hydroxy-1,2,3,4-tetrahydroquinoline is a chemical compound from the tetrahydroquinoline family. It is a hydroxy derivative of tetrahydroquinoline, which is a heterocyclic compound, featuring a four-membered ring fused with a benzene ring. 7-Hydroxy-1,2,3,4-tetrahydroquinoline, being related to a class of molecules that have been studied for their biological activity, could have potential applications in medicinal chemistry. It's important to handle this compound with care as its risks and safety measures have not been fully explored. Its properties such as solubility, stability, and reactivity are crucial factors for chemists in determining its possible applications.

InChI:InChI=1/C9H11NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1,3,5,10-11H,2,4,6H2

Upstream product

• 19500-61-9 7-methoxy-1,2,3,4-tetrahydroquinoline 
• 22246-18-0 7-hydroxy-3,4-dihydro-2-(1H)-quinolinone 
• 153856-89-4 7-amino-1,2,3,4-tetrahydroquinoline 
• 3334-67-6 3-((3-methoxyphenyl)amino)propanoic acid 
• 4964-76-5 7-methoxyquinoline 
• 580-20-1 quinolin-7-ol 
• 7732-18-5 water 
• 7664-93-9 sulfuric acid 
• 1023913-73-6 7-methoxy-3,4-dihydro-2H-quinoline-1-carboxylic acid tert-butyl ester 
• 635-46-1 1,2,3,4-tetrahydroisoquinoline 
• 179897-99-5 1-tert-butoxycarbonyl-1,2,3,4-tetrahydro-7-methyloxy-4-quinolinone 
• 536-90-3 m-Anisidine 
• 879-56-1 7-Methoxy-2,3-dihydro-1H-quinolin-4-one 

Downstream Products

• 71130-68-2 1-ethyl-7-hydroxy-1,2,3,4-tetrahydroquinoline 
• 1441382-72-4 C₄₂H₂₉F₂₆N₂O₃⁽¹⁺⁾*Cl^(1-) 
• 53518-16-4 4-trifluoromethyl-6,7,8,9-tetrahydro-pyrano[3,2-g]quinolin-2-one 
• 94411-96-8 7-hydroxy-1-methyl-1,2,3,4-tetrahydroquinoline 
• 22246-17-9 7-methoxy-2-oxo-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

Development of a C2-Symmetric Chiral aza Spirocyclic Diol

A C2-symmetric chiral spirocyclic diol aza-SPINOL containing a spirooxindole scaffold has been designed, synthesized, and optically resolved. The product could be synthesized on gram scale in an overall yield of 22%. Moreover, elaborations of aza-SPINOL to other chiral ligands as well as the preliminary investigation of the related bisphosphine ligand in the desymmetrization of bisallylic amide were reported.

Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction

Conditionally activated, caged morpholino antisense agents (cMOs) are tools that enable the temporal and spatial investigation of gene expression, regulation, and function during embryonic development. Cyclic MOs are conformationally gated oligonucleotide analogs that do not block gene expression until they are linearized through the application of an external trigger, such as light or enzyme activity. Here, we describe the first examples of small molecule-responsive cMOs, which undergo rapid and efficient decaging via a Staudinger reduction. This is enabled by a highly flexible linker design that offers opportunities for the installation of chemically activated, self-immolative motifs. We synthesized cyclic cMOs against two distinct, developmentally relevant genes and demonstrated phosphine-triggered knockdown of gene expression in zebrafish embryos. This represents the first report of a small molecule-triggered antisense agent for gene knockdown, adding another bioorthogonal entry to the growing arsenal of gene knockdown tools.

NEAR-INFRARED NERVE-SPARING FLUOROPHORES

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