582-54-7

Usage

Uses

Used in Agricultural Industry:
2,4-D is used as a herbicide for controlling broadleaf weeds in various crops and turf. It functions by mimicking the natural plant hormone indole-3-acetic acid, leading to uncontrolled growth and death of the targeted weeds, thus improving crop yield and maintaining the quality of turf areas.
Used in Plant Growth Regulation:
In addition to its herbicidal properties, 2,4-D is also used as a plant growth regulator. It can influence the growth patterns of certain plants, making it a valuable tool in horticulture and agriculture for managing plant development and shaping landscapes.
Despite its widespread use, it is important to consider the potential health and environmental effects associated with 2,4-D, such as its association with certain types of cancer and its impact on non-target plants and animals. This necessitates responsible use and ongoing research into safer alternatives or methods to mitigate its environmental impact.

InChI:InChI=1/C8H6Cl2O3/c9-5-1-2-6(10)7(3-5)13-4-8(11)12/h1-3H,4H2,(H,11,12)

Upstream product

• 583-78-8 2,5-dichlorophenol 
• 79-11-8 chloroacetic acid 
• 105-36-2 ethyl bromoacetate 
• 2009-15-6 2,5-Dichlorphenoxyessigsaeure-methylester 
• 61763-88-0 (2,5-dichloro-phenoxy)-acetic acid ethyl ester 
• 93-76-5 2,4,5-Trichlorophenoxyacetic acid 
• 92696-68-9 tert-butyl 2-(2,5-dichlorophenoxy)acetate 
• 32026-07-6 (2,5-dichloro-phenoxy)-acetic acid amide 

Downstream Products

• 6467-26-1 2,5-Dichlor-4-<2-methylen-butyryl>-phenoxyessigsaeure 
• 1445980-92-6 1-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)-2-(2,5-dichlorophenoxy)ethanone trifluoroacetate 
• 16429-74-6 1-[(2,5-dichloro-phenoxy)-acetyl]-1H-benzoimidazole 
• 61763-88-0 (2,5-dichloro-phenoxy)-acetic acid ethyl ester 
• 55502-51-7 (2,5-dichloro-phenoxy)-acetyl chloride 
• 93-76-5 2,4,5-Trichlorophenoxyacetic acid 

Relevant academic research and scientific papers

Discovery, synthesis and biological characterization of a series of: N -(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1 H -pyrazol-5-yl)acetamide ethers as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of N-(1-(1,1-dioxidotetrahydrothiophen-3-yl)-3-methyl-1H-pyrazol-5-yl)acetamide ethers as G protein-gated inwardly-rectifying potassium (GIRK) channel activators. From our previous lead optimization efforts, we have identified a new ether-based scaffold and paired this with a novel sulfone-based head group to identify a potent and selective GIRK1/2 activator. In addition, we evaluated the compounds in tier 1 DMPK assays and have identified compounds that display nanomolar potency as GIRK1/2 activators with improved metabolic stability over the prototypical urea-based compounds. This journal is

Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action

In order to develop a novel herbicide containing the β-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha-1. Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha-1 under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

An Efficient One-Pot Synthesis of 2-(Aryloxyacetyl)cyclohexane-1,3-diones as Herbicidal 4-Hydroxyphenylpyruvate Dioxygenase Inhibitors

4-Hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27, HPPD) is an important target for new bleaching herbicides discovery. As a continuous work to discover novel crop selective HPPD inhibitor, a series of 2-(aryloxyacetyl)cyclohexane-1,3-diones were rationally designed and synthesized by an efficient one-pot procedure using N,N′-carbonyldiimidazole (CDI), triethylamine, and acetone cyanohydrin in CH2Cl2. A total of 58 triketone compounds were synthesized in good to excellent yields. Some of the triketones displayed potent in vitro Arabidopsis thaliana HPPD (AtHPPD) inhibitory activity. 2-(2-((1-Bromonaphthalen-2-yl)oxy)acetyl)-3-hydroxycyclohex-2-en-1-one, II-13, displayed high, broad-spectrum, and postemergent herbicidal activity at the dosage of 37.5-150 g ai/ha, nearly as potent as mesotrione against some weeds. Furthermore, II-13 showed good crop safety against maize and canola at the rate of 150 g ai/ha, indicating that II-13 might have potential as a herbicide for weed control in maize and canola fields. II-13 is the first HPPD inhibitor showing good crop safety toward canola.

Effective catalytic hydrodechlorination of chlorophenoxyacetic acids over Pd/graphitic carbon nitride

Catalytic hydrodechlorination (HDC) of chlorophenoxyacetic acids was performed over Pd/graphitic carbon nitride (Pd/g-C3N4) catalysts in the present work. A series of Pd/g-C3N4 catalysts were prepared by a deposition-precipitation method, and characterized by X-ray diffraction (XRD), N2 adsorption-desorption, transmission electron microscopy (TEM), CO chemisorption and X-ray photoelectron spectroscopy (XPS). The Pd/g-C3N4 catalysts showed excellent activity to convert dichlorophenoxyacetic acid (2,4-D) into phenoxyacetic acid (PA) and the catalytic activity was correlated with the ratio of Pd2+/(Pd0 + Pd2+) and Pd particle size. In addition, HDC of 2,4-D over Pd/g-C3N4 catalyst followed the Langmuir-Hinshelwood model, indicating an adsorption-controlled mechanism. Other chlorophenoxyacetic acids, such as 2-chlorophenoxyacetic acid (2-CPA), 4-chlorophenoxyacetic acid (4-CPA) and 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) could also be completely dechlorinated to PA over Pd/g-C3N4 catalysts.

NON-SYSTEMIC TGR5 AGONISTS

Compounds of structure (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagonists and for treatment of various indications, including Type II diabetes meletus are also provided.

CHEMICAL COMPOUNDS

This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds.

THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to substituted thiadiazole compounds of the formula (I) and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.

Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase

A novel class of HCV NS5B RNA dependent RNA polymerase inhibitors containing 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H- pyrano[3,4-b]benzofuran scaffolds were designed and synthesized. Optimization of the alkyl substituent in the pyran ring showed preference for an n-propyl group, while 5,8-disubstitution pattern is preferred for the aromatic region. Analog 19 displayed potent activity with an IC50 of 50 nM against HCV NS5B enzyme and was selective over a panel of polymerases.