582-82-1Relevant academic research and scientific papers
New γ-Halo-δ-lactones and δ-Hydroxy-γ-lactones with Strong Cytotoxic Activity
Kamizela, Angelika,Gawdzik, Barbara,Urbaniak, Mariusz,Lechowicz, ?ukasz,Bia?onska, Agata,Kutniewska, Sylwia Ewa,Gonciarz, Weronika,Chmiela, Magdalena
, (2019/05/29)
This paper presents the synthesis of γ-halo-δ-lactones, δ-iodo-γ-lactones and δ-hydroxy-γ-lactones from readily available organic substrates such as trans-crotonaldehyde and aryl bromides. Crystal structure analysis was carried out for lactones that were obtained in crystalline form. All halo-δ-lactones and δ-hydroxy-γ-lactones were highly cytotoxic against gastric cancer AGS cells with IC50 values in the range of 0.0006–0.0044 mM. Some lactones showed high bactericidal activity against E. coli ATCC 8739 and S. aureus ATCC 65389, which reduced the number of CFU/mL by 70–83% and 87% respectively.
A mesoporous-silica-immobilized oxovanadium cocatalyst for the lipase-catalyzed dynamic kinetic resolution of racemic alcohols
Egi, Masahiro,Sugiyama, Koji,Saneto, Moriaki,Hanada, Ryosuke,Kato, Katsuya,Akai, Shuji
supporting information, p. 3654 - 3658 (2013/04/23)
V for resolution: A new oxovanadium catalyst (V-MPS; see scheme) immobilized in the pores of mesoporous silica has been developed. The combined use of V-MPS and lipases achieved the dynamic kinetic resolution of a wide range of racemic alcohols (1 or 2) t
