58207-03-7Relevant articles and documents
MACROCYCLES IN THE CONSTRUCTION OF ACYCLIC STEREOCHEMISTRY
Still, W. Clark,MacPherson, Lawrence J.,Harada, Toshiro,Callahan, James F.,Rheingold, Arnold L.
, p. 2275 - 2282 (1984)
The conformations of macrocyclic intermediates provide a useful medium through which distant chiral centers may control chemical reactions.In this paper, we show that macrocycles made by cyclization of simple acyclic starting materials with an auxiliary spacer may be used to prepare stereochemically complex acyclic products.
Isolation and structure determination of an antimicrobial ester from a marine sediment-derived bacterium
Schumacher, Robert W.,Talmage, Stephanie C.,Miller, Sara A.,Sarris, Katie E.,Davidson, Bradley S.,Goldberg, Arthur
, p. 1291 - 1293 (2007/10/03)
A new compound, assigned the trivial name bonactin (1), has been isolated from the liquid culture of a Streptomyces sp. BD21-2 obtained from a shallow-water sediment sample collected at Kailua Beach, Oahu, Hawaii. Structure elucidation employed one- and two-dimensional NMR, HRFABMS, IR, and chemical analysis. Bonactin displayed antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as antifungal activity.
A shortcut to the smaller fragment of pamamycin-607
Bernsmann, Heiko,Gruner, Margit,Fr?hlich, Roland,Metz, Peter
, p. 5377 - 5380 (2007/10/03)
Starting from a key intermediate for the synthesis of the larger hydroxy acid constituent of pamamycin-607 (1), an efficient three-step route to the methyl ester of the smaller fragment of 1 involving a Yamaguchi lactonization with concomitant C(2) epimerization was developed. Alternatively, the methyl ester of the smaller hydroxy acid portion of 1 was prepared by direct C(2) epimerization.
