58207-45-7

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 622-33-3 N-benzyloxyamine 
• 115364-82-4 (S)-tert-butyl (1-((benzyloxy)amino)-1-oxo-3-phenylpropan-2-yl)-carbamate 

Downstream Products

• 612815-61-9 [(S)-1-((S)-1-Benzyloxycarbamoyl-2-phenyl-ethylcarbamoyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Solid-phase synthesis of conformationally constrained peptidomimetics based on a 3,6-disubstituted-1,4-diazepan-2,5-dione core

Starting from a Cl-trytyl linked hydroxylamine, a hydroxamic dipeptide having serine in the second position was prepared by using DMTMM as the coupling agent. Mitsunobu cyclization carried out under microwave heating gave very good yields of a 3,6-disubstituted-perhydro-diazepin-2,5-dione. This heterocycle can be used as a new platform for combinatorial chemistry or as a constraint to rigidify a small peptide.