58219-97-9Relevant articles and documents
Preparation method of 1, 1, 1-trifluoroisopropylamine
-
Paragraph 0043-0052; 0058-0072, (2021/05/05)
The invention discloses a preparation method of 1, 1, 1-trifluoroisopropylamine, which comprises the following steps: (1) reacting 1, 1, 1-trifluoroisopropanol serving as a raw material with a sulfonyl chloride compound under the action of organic alkali to obtain a 1, 1, 1-trifluoroisopropyl sulfonate compound; (2) carrying out amination reaction on the 1, 1, 1-trifluoroisopropyl sulfonate compound and ammonia gas in a polar aprotic solvent; and (3) rectifying the reaction liquid to obtain the 1, 1, 1-trifluoroisopropylamine. The method has the advantages of easily available raw materials, mild conditions, high yield and the like, and is suitable for industrial large-scale production.
Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: Improved labelling procedures
Riss, Patrick J.,Ferrari, Valentina,Brichard, Laurent,Burke, Paul,Smith, Robert,Aigbirhio, Franklin I.
, p. 6980 - 6986,7 (2012/12/12)
A rapid and efficient protocol to afford the title compound 2-[ 18F]-fluoro-2,2-difluoroethyl tosylate ([18F]7b) is described. Starting from [18F]fluoride ion, labelling reagent 7b was obtained in good yields and a high specific radioactivity. Compound ([ 18F]7b) was then used to synthesise a prospective radiotracer for PET-imaging in dementia.
Facile Synthesis of Trifluoro- and Hexafluoroisopropyl Halides
Hanack, Michael,Ullmann, Joerg
, p. 1432 - 1435 (2007/10/02)
-
