421-49-8

Basic information

• Product Name: 1,1,1-TRIFLUORO-ISOPROPYLAMINE
• Synonyms: 1,1,1-TRIFLUORO-ISOPROPYLAMINE;1,1,1-trifluoropropan-2-amine;(2,2,2-trifluoro-1-methylethyl)amine(SALTDATA: HCl);(2,2,2-Trifluoro-1-methylethyl)amine;2-Amino-1,1,1-trifluoropropane;1,1,1-Trifluoro-2-propanaMine;1,1,1-Trifluoro-2-aMinopropane;1,1,1-Trifluoroprop-2-ylaMine
• CAS NO: 421-49-8
• Molecular Formula: C₃H₆F₃N
• Molecular Weight: 113.08
• Product Categories: Aromatics;Intermediates
• Mol File: 421-49-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 0°C
• Boiling Point: 0°C
• Flash Point: 0°C
• Appearance: /
• Density: 1.148 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 5.82±0.50(Predicted)
• CAS DataBase Reference: 1,1,1-TRIFLUORO-ISOPROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRIFLUORO-ISOPROPYLAMINE(421-49-8)
• EPA Substance Registry System: 1,1,1-TRIFLUORO-ISOPROPYLAMINE(421-49-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• RIDADR: 2734
• HazardClass: IRRITANT
• Hazardous Substances Data: 421-49-8(Hazardous Substances Data)

Usage

Uses

1-(Trifluoromethyl)ethylamine is a flurorinated propanamine derivative used as a building block in the synthesis of pharmaceutical compounds such as hNav1.7 channel blockers and anti-cancer agents.

Upstream product

• 119561-24-9 N-benzylidene(1,1,1-trifluoroisopropyl)amine 
• 58219-97-9 1,1,1-trifluoropropan-2-yl 4-methylbenzenesulfonate 
• 917-64-6 methyl magnesium iodide 
• 353-85-5 trifluoroacetonitrile 
• 302-72-7 rac-Ala-OH 
• 34226-10-3 1,1,1-trifluoropropanone oxime 
• 431-40-3 1,1,1-trifluoro-propanone-oxime 
• 119561-23-8 N-1,1,1-trifluoropropan-2-ylidene-1-phenylmethanamine 

Downstream Products

• 849549-79-7 C₂₄H₂₉F₃N₂O 
• 125278-10-6 (S)-1,1,1-trifluoropropan-2-amine 
• 1589570-32-0 (R)-N-(1,1,1-trifluoropropan-2-yl)acetamide 

Relevant articles and documents

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Economical and practical strategies for synthesis of α-trifluoromethylated amines

A powerful approach to synthesize α-trifluoromethylated amines has been developed. The method is operationally simple, broad in substrate scope and amenable to scale-up using trifluoroacetic anhydride. Meanwhile, the strategy not only provided a versatile approach to synthesize α-trifluoromethylated amines but also provides a new method for exploring the new reactivity of trifluoroacetic anhydride.

Biomimetic reductive amination under the continuous-flow reaction conditions

This study present a full account of continuous-flow reaction conditions for biomimetic reductive amination of fluorinated carbonyl compounds to corresponding amines and amino acids of biomedical importance. We demonstrate that simple silica-adsorbed DBU can be used as efficient catalysts for on-column 1,3-proton shift reaction, a key transformation in the biomimetic reductive amination process. This new on-column process features operationally convenient conditions, higher chemical yields, enantioselectivity and purity of the corresponding products as compared with traditional in-flask reactions. Moreover the removal of base-catalyst, the most delicate problem of the in-flask reactions, is not an issue in the on-column process, as the silica-adsorbed DBU or polymer-bound guanidine remains on the column and can be reused. This feature renders the overall process substantially more economical and synthetically efficient, in particular, for large-scale synthesis of the corresponding fluorinated amines and amino acids target.