5822-16-2

Basic information

• Product Name: Benzenemethanamine, 4-chloro-N-(2-nitrophenyl)-
• CAS NO: 5822-16-2
• Molecular Formula: C13H11ClN2O2
• Molecular Weight: 262.696
• Mol File: 5822-16-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzenemethanamine, 4-chloro-N-(2-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanamine, 4-chloro-N-(2-nitrophenyl)-(5822-16-2)
• EPA Substance Registry System: Benzenemethanamine, 4-chloro-N-(2-nitrophenyl)-(5822-16-2)

Safety Data

• Hazardous Substances Data: 5822-16-2(Hazardous Substances Data)

Upstream product

• 104-86-9 4-chlorobenzylamine 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 3689-76-7 Chlormidazole 
• 107456-42-8 1-(4-chlorobenzyl)-1H-benzo[d]imidazole 
• 1019-85-8 2-(4-chlorophenyl)benzimidazole 
• 101103-28-0 chloro-acetic acid-[2-(4-chloro-benzylamino)-anilide] 
• 442-52-4 clemizole 
• 805965-34-8 [1-(4-chloro-benzyl)-1H-benzimidazol-2-ylmethyl]-dimethyl-amine 
• 7189-18-6 1-(4-chlorobenzyl)-2-(chloromethyl)-1H-benzo[d]imidazole 
• 131705-70-9 N-(p-Chlorophenylmethyl)-2(1H)-benzimidazolone 
• 131705-80-1 2-Chloro-1-(p-chlorophenylmethyl)-1H-benzimidazole 
• 5729-18-0 N-(p-Chlorophenylmethyl)-2-amino aniline 

Relevant articles and documents

CuBr-Catalyzed Oxidation/Coupling: An Efficient and Applicable Strategy for the Synthesis of 2-Aryl Benzimidazoles from 1-Fluoro-2-nitrobenzene and Benzylamines

A novel and efficient route has been developed for the synthesis of benzimidazole derivatives via ligand-free CuBr-catalyzed oxidation and cyclization of 1,2-diamines derived from 1-fluoro-2-nitrobenzene and different arylamines as starting materials. GRAPHICAL ABSTRACT.

BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF

Disclosed are compounds according to Formula (I) or (II), and pharmaceutical compositions comprising them. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (I) or (II). (Formulae (II), (III))

Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis

This article describes discovery of a novel and new class of cholinesterase inhibitors as potential therapeutics for Alzheimer's disease. A series of novel isoalloxazine derivatives were synthesized and biologically evaluated for their potential inhibitory outcome for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). These compounds exhibited high activity against both the enzymes AChE as well as BuChE. Of the synthesized compounds, the most potent isoalloxazine derivatives (7m and 7q) showed IC50 values of 4.72 μM and 5.22 μM respectively against AChE; and, 6.98 μM and 5.29 μM respectively against BuChE. These two compounds were further evaluated for their anti-aggregatory activity for β-amyloid (Aβ) in presence and absence of AChE by performing Thioflavin-T (ThT) assay and Congo red (CR) binding assay. In order to evaluate cytotoxic profile of these two potential compounds, cell viability assay of SH-SY5Y human neuroblastoma cells was performed. Further, to understand the binding behavior of these two compounds with AChE and BuChE enzymes, docking studies have been reported.