5823-12-1

Basic information

• Product Name: TRIETHYL 2,2-DICHLORO-2-PHOSPHONOACETATE
• Synonyms: TRIETHYL 2,2-DICHLORO-2-PHOSPHONOACETATE;DIETHYL DICHLORO ETHOXYCARBONYLMETHYL PHOSPHONATE;LABOTEST-BB LT00452250;Diethyl dichloro ethoxycarbonylmethyl phosphonate, 98 %;Ethyl 2,2-dichloro-2-diethylphosphonoacetate;Triethyl 2,2-dichloro-2-phosphonoacetate 98%
• CAS NO: 5823-12-1
• Molecular Formula: C₈H₁₅Cl₂O₅P
• Molecular Weight: 293.08
• Product Categories: Organic Building Blocks;Phosphonates/Phosphinates;Phosphorus Compounds
• Mol File: 5823-12-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 84-86 °C0.01 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.289 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000513mmHg at 25°C
• Refractive Index: n20/D 1.456(lit.)
• CAS DataBase Reference: TRIETHYL 2,2-DICHLORO-2-PHOSPHONOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIETHYL 2,2-DICHLORO-2-PHOSPHONOACETATE(5823-12-1)
• EPA Substance Registry System: TRIETHYL 2,2-DICHLORO-2-PHOSPHONOACETATE(5823-12-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 5823-12-1(Hazardous Substances Data)

Usage

Uses

Ethyl 2,2-Dichloro-2-diethoxyphosphorylacetate acts as a reagent in the synthesis of halogenated phosphonoacetate esters. It is also used as a reagent for cotton insecticides preparations.

InChI:InChI=1/C8H15Cl2O5P/c1-4-13-7(11)8(9,10)16(12,14-5-2)15-6-3/h4-6H2,1-3H3

Upstream product

• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 66051-41-0 ethyl (2-chlorocyclohexylidene)acetate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 7071-12-7 triethyl 2-chloro-2-phosphonoacetate 
• 66051-39-6 (Z)-methoxyphenyl-3 chloro-2 propenoate d'ethyle 
• 66051-40-9 (E)-methoxyphenyl-3 chloro-2 propenoate d'ethyle 
• 26880-33-1 ethyl 2-chloro-3-phenylacrylate 
• 66051-35-2 ethyl (E)-2-chloro-3-phenyl-2-propenoate 
• 66051-36-3 ethyl (Z)-2-chloro-3-phenyl-2-propenoate 

Relevant articles and documents

Phosphonate-terminated poly(vinyl acetate) synthesized by RAFT/MADIX polymerization

Four different xanthates containing either phosphonate or bisphosphonate moieties were synthesized with high degree of purity. These xanthates were used as chain transfer agents (CTA) in the RAFT/MADIX polymerization of vinyl acetate (VAc) to prepare end-capped poly(VAc). The rate of VAc polymerization in the presence of these new CTAs was shown to be similar to that obtained with conventional xanthate, that is, (methyl ethoxycarbonothioyl) sulfanyl acetate. Good control of VAc polymerization was also obtained since the molecular weight increased linearly with monomer conversion for each phosphonate-containing xanthate. Low-PDI values were obtained, ascribed to efficient exchange during RAFT/MADIX polymerization. Cex value was therefore calculated to about 25, based on RAFT/MADIX of VAc in the presence of rhodixan A1/VAc adduct.

INHIBITORS OF BRUTON'S TYROSINE KINASE AND METHODS OF THEIR USE

The present disclosure is directed to compounds of formula I and methods of their use and preparation, as well as compositions comprising compounds of formula I.

Synthesis of Halogenated Phosphonoacetate Esters

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