582332-75-0

Upstream product

• 2919-23-5 cyclobutanol 
• 626-02-8 3-Iodophenol 
• 582333-29-7 acetic acid 3-cyclobutoxy-phenyl ester 

Downstream Products

• 1352570-84-3 (3-cyclobutoxyphenoxy)triisopropylsilane 
• 1352570-85-4 (3-cyclobutoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)triisopropylsilane 
• 1352570-86-5 2-(3-cyclobutoxy-5-(triisopropylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)pyrimidine 
• 1352570-87-6 3-cyclobutoxy-5-(4-(4-methoxybenzyloxy)pyrimidin-2-yl)phenol 

Relevant academic research and scientific papers

2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES

O N NH R3 R2 O R1 168 ABSTRACT The present invention provides a 2-(3,5-disubstitutedphenyl)pyrimidin- 4(3H)-one compound of Formula (I) 5 (I) or a pharmaceutically acceptable salt thereof wherein R 1, R2 and R3 are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and 10 the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.

Nicotinamide derivatives and a tiotropium salt in combination for the treatment of diseases

The invention relates to a combination of a nicotinamide derivative and tiotropium or a derivative thereof, compositions containing it and the uses of, such a combination. The combination according to the present invention is useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.