58246-54-1Relevant academic research and scientific papers
A highly enantioselective, moderately anti-selective aldol reaction using a novel hydrazone moiety as stereo director
McGlacken, Gerard P.,Breeden, Simon W.
, p. 3615 - 3618 (2007/10/03)
The use of novel hydrazones as stereo directors with a view to develop a highly enantioselective, anti-diastereoselective aldol addition procedure has been investigated. A number of proline-derived hydrazones were produced and their effectiveness in direc
Synthesis and conformational behaviour of 2-phenylperhydropyrrolo[1,2-4][1,3,4]oxadiazine and 2-phenylperhydropyrido[1,2-d][1,3,4]oxadiazine; new heterocyclic ring systems
Rosling, Ari,Fueloep, Ferenc,Sillanpaeae, Reijo,Mattinen, Jorma
, p. 95 - 106 (2007/10/03)
Hydrazino alcohols, 1-amino-2-hydroxymethylpyrrolidine (1) and 1-amino-2-hydroxymethylpiperidine (2), were synthesized and subsequently ring closured with ethyl benzimidate to the title compounds (7) and (8), which have new ring systems. Variabletemperature 1H nmr measurements, supported by X-ray analysis, indicated that pyrrolo[1,2-d][1,3,4]oxadiazine (7) exists exclusively in a cis-fused conformation (in CDCl3 at room temperature), whereas pyrido[1,2-d][1,3,4]oxadiazine (8) adopts a trans-fused conformation.
CHIROPTICAL PROPERTIES OF N-NITROSOPYRROLIDINES AND N-NIROSAMINO ACIDS
Gaffield, William,Lundin, Robert E.,Keefer, Larry K.
, p. 1861 - 1869 (2007/10/02)
CD data for a variety of N-nitrosamino acids and N-nitrosopyrrolidines are presented.The effects of nitrosamino group conformation, pyrrolidine ring geometry, different perturbing substituents, and especially intramulecular H-bonding upon the n?* CD band are discussed.Stereochemical conclusions can be made with confidence in many cases, although no sector diagram, as yet published, succesfully correlates all the available chiroptical data in this series of compounds.However, a negative CD band due to the ??* transition was observed for all N-nitrosamines having the L-proline configuration at C-2, regardless of nitroso group conformation; it is suggested that this band be used whenever possible for stereochemical correlations.
