58249-25-5

Usage

Uses

Used in Paints and Coatings Industry:
1,2-Benzisothiazol-3(2H)-one, sodium salt is used as a preservative and biocide for preventing microbial growth in paints and coatings. Its strong antimicrobial properties help maintain the quality and longevity of the products by inhibiting the growth of bacteria, fungi, and other microorganisms.
Used in Adhesives Industry:
In the adhesives industry, 1,2-benzisothiazol-3(2H)-one, sodium salt is used as a fungicide and biocide to protect adhesives from microbial contamination. Its addition to adhesive formulations helps prevent spoilage and degradation, ensuring the adhesives' performance and durability.
Used in Personal Care Industry:
1,2-Benzisothiazol-3(2H)-one, sodium salt is used as a preservative in personal care products, such as cosmetics, toiletries, and skincare items. Its antimicrobial properties help prevent the growth of harmful microorganisms, ensuring the safety and efficacy of these products for consumers.
Used in Water Treatment:
1,2-Benzisothiazol-3(2H)-one, sodium salt is used in water treatment processes as a biocide to control the growth of microorganisms in water systems. Its strong antimicrobial action helps prevent the formation of biofilms and the spread of waterborne diseases.
Used in Pulp and Paper Industry:
In the pulp and paper industry, 1,2-benzisothiazol-3(2H)-one, sodium salt is used as a biocide and preservative to protect pulp and paper products from microbial contamination. Its addition to the manufacturing process helps maintain the quality and integrity of the final products.
Used in Textile Industry:
1,2-Benzisothiazol-3(2H)-one, sodium salt is used in the textile industry as a biocide and fungicide to protect fabrics and garments from microbial growth. Its antimicrobial properties help prevent the development of odors, stains, and deterioration caused by microorganisms.

InChI:InChI=1/C7H5NOS.Na/c9-7-5-3-1-2-4-6(5)10-8-7;/h1-4H,(H,8,9);/q;+1

Upstream product

• 2634-33-5 1,2-benzisothiazolin-3-one 

Downstream Products

• 30757-70-1 3-oxo-1,2-benzisotiazolin-2-ilcarbossilato etilico 
• 82152-06-5 2-(3-Oxo-3h-benzo[d]isothiazol-2-yl)-acetic acid 
• 40991-40-0 3-butoxy-1 ,2-benzisothiazolin-3-one 
• 4299-07-4 2-butyl-1,2-benzothiazolin-3-one 
• 58249-29-9 2-benzoyl-3,4-dihydro-1,1-dioxide-1,3-2H-benzothiazin-4-one 
• 58249-30-2 2-((1,1-dioxidobenzo[d]isothiazol-3-yl)oxy)-1-phenylethan-1-one 
• 58249-28-8 2-benzoyl-1-oxo-2,3-dihydro-1H-1λ⁴-benzo[e][1,3]thiazin-4-one 
• 58249-27-7 2-benzoyl-2,3-dihydro-benzo[e][1,3]thiazin-4-one 

Relevant academic research and scientific papers

Palladium(II) benzisothiazolinate (bit) complexes with amino-, acetylamino-, heterocyclic and phosphine co-ligands. Crystal structure of [Pd(bit)2(κ2-dppe)]·2EtOH

Abstract A series of square-planar palladium(II) benzisothiazolinate (bit) of the general type [Pd(bit)2L2] have been prepared and characterized by analytical and spectroscopic methods. Two synthetic routes have been employed, namely reactions of [Pd(bit)2]·H2O with two equivalents of ligands (L = amine, amide, phosphine) or nucleophile displacement of chloride by benzisothiazolinate starting from trans-[PdCl2L2]. Both routes afford the new complexes in good yields as easily isolated, air and moisture stable, colored solids. The precursor, [Pd(bit)2]·H2O, is itself prepared in high yields upon reaction of Na[bit] with Na2[PdCl4] in methanol and the analogous platinum complex, [Pt(bit)2]·H2O, is similarly prepared from K2[PtCl4]. It is not clear if these species are mono- or dimeric, and formulation as [M2(μ-bit)4(H2O)2] with the four benzisothiazolinate spanning the metal-metal vector and possibly binding through coordination of nitrogen and oxygen is suggested. Diphosphine adducts, cis-[Pd(bit)2{κ2-Ph2P(CH2)nPPh2}] (n = 1-4) can be prepared both upon addition of the diphosphine to [Pd(bit)2]·H2O and from reactions of cis-[PdCl2{κ2-Ph2P(CH2)nPPh2}] with two equivalents of Na[bit]. A crystal structure of cis-[Pd(bit)2(κ2-dppe)] reveals that the benzisothiazolinate ligands are bonded in a monodentate fashion through nitrogen and this binding mode is proposed for all [Pd(bit)2L2] and [Pd(bit)2L] complexes. With dppb (n = 4) a second product is seen by NMR spectroscopy being proposed to be the part-substituted complex cis-[PdCl(bit)(κ2-dppb)], while with dppm (n = 1) two further products are seen spectroscopically, proposed as trans-[Pd(bit)2(κ1-dppm)2] and (more tenuously) [Pd2(bit)4(dppm)2]. The former is also prepared in good yields from reaction of [Pd(κ2-dppm)2]Cl2 with Na[bit]. These studies show that palladium benzisothiazolinate are easily accessed and show good air and moisture stability.

Synthesis and bioactivity of novel 2-(1,2-benzisothiazol-3-yloxy)-N-(1-aryl-3-cyanopyrazol-5-yl) acetamides

Nine novel types of 2-(1,2-benzisothiazol-3-yloxy)-N-(1-aryl-3-cyanopyrazol-5-yl)-acetamides were synthesized, and their inhibition effects on selected bacteria (heterotrophic bacteria) and algae (marine chlorella) were evaluated. Results showed that 2-(1,2-benzisothiazol-3-yloxy)-N-(3-cyano-1-(2,4-dimethylphenyl)pyrazol-5-yl) acetamide achieved the highest yield of 81% with good bioactivity against heterotrophic bacteria and marine chlorella.

2-butyl-1,2-benzisothiazolin-3-one preparation method

The present invention discloses a 2-butyl-1,2-benzisothiazolin-3-one synthesis process, which comprises that (1) a starting raw material BIT reacts with an alkali to form a BIT salt; and (2) the BIT salt reacts with halogenated n-butane to obtain the target product 2-butyl-1,2-benzisothiazolin-3-one (BBIT). The present invention further discloses a separation and purification method of 2-butyl-1,2-benzisothiazolin-3-one, wherein an acid is added to a mixture containing BBIT to make the BBIT form the salt, and the obtained BBIT salt is alkalized so as to obtain the high purity BBIT. According to the present invention, the synthesis method has advantages of easily available raw materials, mild reaction condition, high yield, low cost, low environmental pollution and convenient industrial production; and with the separation and purification method, the high purity target product can be obtained, and the method can be widely used for industrial production.

Process for preparing benzisothiazolinones

N-alkylated 1,2-benzisothiazolin-3-ones can be prepared in good yield and good selectivity by reaction of the lithium salt of 1,2-benzisothiazolin-3-one with an electrophilic alkylating agent.