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4299-07-4

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4299-07-4 Usage

Uses

2-Butyl-1,2-benzisothiazolin-3-one is a heterocyclic organic compound and can be used as a pharmaceutical intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 4299-07-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,9 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 4299-07:
(6*4)+(5*2)+(4*9)+(3*9)+(2*0)+(1*7)=104
104 % 10 = 4
So 4299-07-4 is a valid CAS Registry Number.

4299-07-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-butyl-1,2-benzothiazol-3-one

1.2 Other means of identification

Product number -
Other names 2-butyl-1,2-benzisothiazolin-3-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4299-07-4 SDS

4299-07-4Downstream Products

4299-07-4Relevant articles and documents

Facile synthesis and in vitro activity of n-substituted 1,2-benzisothiazol-3(2H)-ones against dengue virus NS2BNS3 protease

Batool, Farwa,Saeed, Muhammad,Saleem, Hafiza Nosheen,Kirschner, Luisa,Bodem, Jochen

, (2021/04/28)

Several new N-substituted 1,2-benzisothiazol-3(2H)-ones (BITs) were synthesised through a facile synthetic route for testing their anti-dengue protease inhibition. Contrary to the conventional multistep synthesis, we achieved structurally diverse BITs with excellent yields using a two-step, one-pot reaction strategy. All the synthesised compounds were prescreened for drug-like properties using the online Swiss Absorption, Distribution, Metabolism and Elimination (SwissADME) model, indicating their favourable pharmaceutical properties. Thus, the synthesised BITs were tested for inhibitory activity against the recombinant dengue virus serotype-2 (DENV-2) NS2BNS3 protease. Dose–response experiments and computational docking analyses revealed that several BITs bind to the protease in the vicinity of the catalytic triad with IC50 values in the micromolar range. The DENV2 infection assay showed that two BITs, 2-(2-chlorophenyl)benzo[d]isothiazol-3(2H)-one and 2-(2,6-dichlorophenyl)benzo[d]isothiazol-3(2H)-one, could suppress DENV replication and virus infectivity. These results indicate the potential of BITs for developing new anti-dengue therapeutics.

Method for synthesizing 2-butyl-1, 2-benzisothiazoline-3-ketone

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Paragraph 0044-0049, (2021/02/06)

The invention discloses a method for synthesizing 2-butyl-1, 2-benzisothiazoline-3-ketone. The method comprises the following steps: reacting n-butylamine with a chlorobenzene solution of triethylamine 25% o-methylthiobenzoyl chloride to obtain a mixed solution of N-butyl o-methylthiobenzamide, and filtering the mixed solution of N-butyl o-methylthiobenzamide, and obtaining chlorobenzene solutionand solids of N-butyl o-methylthiobenzamide, reacting the solid with liquid caustic soda to obtain triethylamine, reacting the chlorobenzene solution of N-butyl o-methylthiobenzamide with water, and carrying out reduced pressure distillation to separate chlorobenzene. The method has the advantages of simple process steps, low cost, high yield, recyclability and the like.

Synthetic method 1-2 - benzisothiazol -3 -one compound (by machine translation)

-

, (2020/09/09)

The invention discloses a synthetic method of 1-2 - benzisothiazol -3 -one compound, and belongs to the field of chemical synthesis. 2 - 1-benzisothiazol 2 -one compounds are synthesized through acid chlorination, amidation and cyclization reaction by using the sulfenyl-substituted benzoic acid extracted from BIT process -3 - waste water as a starting raw material. The method disclosed by the invention has the advantages of mild reaction conditions, simple and convenient operation, strong practicability, less waste water, high product purity and the like, and is suitable for large-scale industrial production. The technical scheme provided by the invention is resource utilization and preparation 1 of wastewater extract produced in BIT production, and a feasible method is provided for the 2 -benzisothiazol -3 -one compound. (by machine translation)

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