58266-31-2

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 115-77-5 Pentaerythritol 
• 2425-41-4 5,5-dihydroxymethyl-2-phenyl-1,3-dioxane 
• 2209-89-4 (2-phenyl-1,3-dioxane-5,5-diyl)di(methylene) bis(4-methylbenzenesulfonate) 
• 64-19-7 acetic acid 

Relevant academic research and scientific papers

Synthesis of functionalised derivatives of pentaerythritol

Ring opening of the dibenzylidene derivative of pentaerythritol 12 with N-bromosuccinimide gave di-O-benzoyldibromodideoxypentaerythritol (29). Reaction of 20 and 21 with hydrogen bromide in acetic acid afforded di-O-acetyl-di-O-p-toluenesulfonyl pentaerythritol (26). Nucleophilic displacement of the tosyloxy groups in 20 by 1,2,4 triazole afforded 2-phenyl-5-(p-toluenesulfonyloxymethyl)-5-(1,2,4-triazolylmethyl)-1,3-dioxan (31) and 2-phenyl-5,5-bis(1,2,4-triazolylmethyl)-1,3-dioxan (32), and with benzotriazole gave 2-phenyl-5,5-bis(benzotriazolylmethyl)-1,3-dioxan (30). The activity of various derivatives against hepatitis B virus has been studied.