58271-62-8

Usage

Class

Amine

Physical state

White crystalline solid

Primary use

Reagent in chemical synthesis

Known for

Acting as a chiral auxiliary in asymmetric synthesis

Industry application

Pharmaceutical industry for producing enantiopure compounds

Utilized as

Precursor in the synthesis of various pharmaceutical drugs

Potential applications

Development of new drug candidates

Additional use

Building block for creating diverse chemical libraries for drug discovery

Upstream product

• 108-85-0 1-bromocyclohexane 
• 712-50-5 Cyclohexyl phenyl ketone 
• 1136-58-9 N-[cyclohexyl(phenyl)methylidene]hydroxylamine 
• 180399-94-4 N-(Diethoxyphosphoryl)benzylideneimine 

Downstream Products

• 872828-70-1 cyclohexyl-phenyl-methyl isocyanate 

Relevant academic research and scientific papers

N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

N6-SUBSTITUTED ADENOSINE DERIVATIVES, N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

Synthesis of α-arylalkylamines by addition of Grignard reagents to N- (diethoxyphosphoryl)aldimines

Addition of organomagnesium bromides to N-(diethoxyphosphoryl) aldimines 1 carded out in tetrahydrofuran at 20-25°C affords diethyl N-alkyl- phosphoramidates 2a-w in high yields and spectroscopic purity. Deprotection of the latent amino groups in 2 results in the formation of α-arylalkylamine hydrochlorides 3a-w.