58272-07-4Relevant academic research and scientific papers
Pd-catalyzed amidation of 1,3-diketones with CO and azidesviaa nitrene intermediate
Gu, Zheng-Yang,Chen, Jie,Xia, Ji-Bao
, p. 11437 - 11440 (2020/10/12)
An efficient Pd-catalyzed amidation of 1,3-diketones has been developed using carbon monoxide and organic azides. This reaction provides a step-economic approach to produce β-ketoamides from readily available compounds under mild ligand-, oxidant-, and base-free conditions. The mechanistic studies showed that the reaction occurred through anin situgenerated isocyanate intermediate.
Novel method for synthesizing sulfonyl ketoamide
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Paragraph 0031-0038, (2020/06/09)
The invention discloses a novel method for synthesizing sulfonyl ketoamide, which comprises the following steps: adding a 1,3-dicarbonyl compound, organic azide, a catalyst and a solvent, and introducing CO to react; removing the solvent under reduced pressure; and carrying out column chromatography by using an eluting agent to obtain a sulfonyl ketoamide derivative. In the process of synthesizingthe sulfonyl ketoamide derivative, various 1,3-dicarbonyl compounds, CO and sulfonyl azide are used as raw materials, the organic azide is used for replacing unstable isocyanate, the reaction substrate range is greatly enlarged, the raw materials are simple and easy to obtain, reaction conditions are mild, the method is environmentally friendly, no additive is needed, and the yield is high.
