7307-04-2

Usage

Uses

Used in Pharmaceutical Industry:
2,2-DIMETHYL-3,5-HEXANEDIONE is used as a reactant for the synthesis of RhIII (Rhodium III) and IrIII (Iridium III) half sandwich compounds. These compounds exhibit potent antimicrobial properties, particularly against Mycobacterium smegmatis, which is a significant pathogen responsible for various mycobacterial infections. The synthesis of these compounds with 2,2-DIMETHYL-3,5-HEXANEDIONE contributes to the development of new antimicrobial agents to combat drug-resistant strains of bacteria.
Used in Chemical Synthesis:
2,2-DIMETHYL-3,5-HEXANEDIONE is also used as an intermediate in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique structure allows for a wide range of reactions, making it a valuable building block in the chemical industry.

InChI:InChI=1/C8H14O2/c1-6(9)5-7(10)8(2,3)4/h5,10H,1-4H3

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 108-24-7 acetic anhydride 
• 60-29-7 diethyl ether 
• 141-52-6 sodium ethanolate 
• 141-78-6 ethyl acetate 
• 677-22-5 tert-butylmagnesium chloride 
• 3938-95-2 2,2-dimethyl-propanoic acid ethyl ester 
• 67-64-1 acetone 
• 59892-35-2 5,5-dimethyl-hexane-2,4-dione 2-enol tautomer 
• 33663-62-6 5-amino-2,2-dimethylhex-4-en-3-one 
• 3282-30-2 pivaloyl chloride 
• 92310-74-2 N-(3,3-dimethylbutan-2-ylidene)(phenyl)methanamine 

Downstream Products

• 75-97-8 3,3-dimethyl-butan-2-one 
• 64-19-7 acetic acid 
• 67-64-1 acetone 
• 75-98-9 Trimethylacetic acid 
• 60600-49-9 2,2-dimethyl-5-phenylaminohex-4-en-3-one 
• 103214-12-6 4-Methoxy-benzoic acid [1,4,4-trimethyl-3-oxo-pent-(E)-ylidene]-hydrazide 
• 113561-34-5 3,4-Dihydro-1-pivaloyl-2-oxo-4-hydroxycyclopenta<1>phenanthrene 
• 103214-14-8 4-Bromo-benzoic acid [1,4,4-trimethyl-3-oxo-pent-(E)-ylidene]-hydrazide 
• 103214-15-9 3-Bromo-benzoic acid [1,4,4-trimethyl-3-oxo-pent-(E)-ylidene]-hydrazide 
• 103214-11-5 4-Dimethylamino-benzoic acid [1,4,4-trimethyl-3-oxo-pent-(E)-ylidene]-hydrazide 
• 96440-80-1 3-tert-butyl-5-methyl-1H-pyrazole 
• 82755-28-0 3-tert-Butyl-5-methyl-3,4-dihydro-2H-pyrazol-3-ol 
• 82755-32-6 5-tert-Butyl-3-methyl-3,4-dihydro-2H-pyrazol-3-ol 
• 96440-80-1 5-tert-butyl-3-methylpyrazole 

Relevant academic research and scientific papers

METHOD FOR EXTRACTING ASYMMETRIC B-DIKETONE COMPOUND FROM B-DIKETONE COMPOUND

The present invention provides a method of extracting an asymmetric β-diketone compound from a β-diketone compound containing at least one symmetric β-diketone compound mixed in the asymmetric β-diketone compound, and the method includes the step (A) of adjusting a pH of a mixed solution of the β-diketone compound and water at 11.5 or more and dissolving the β-diketone compound into water to form a β-diketone compound solution and the step (B) of subsequently adjusting the pH of the β-diketone compound solution at 9.5 or less and recovering the asymmetric β-diketone compound of Chemical Formula 1 separated from the β-diketone compound solution. The present invention further includes at least either (a) a step of setting the upper limit of the pH of the mixed solution to 12.5 to form a β-diketone compound solution in the step (A) and bringing the β-diketone compound solution into contact with a hydrophobic solvent or (b) a step of setting the lower limit of the pH of the β-diketone compound solution to 8.0 in the step (B).

Steric vis-à-vis electronic influence of phosphines on biaryl motif: Ligand design for coupling reactions with Chloroarenes

In order to assess relative contribution of steric factors and electron-richness of phosphine ligands on biaryl-type scaffolds, a set of 1-aryl-pyrazole/pyrrole derived ligands L1-L6 featuring either aryldicyclohexylphosphino or aryldiphenylphosphino donor group was synthesized. A bidentate coordination mode of ligands L1 or L2 was evident from a representative crystal structure that implied a possible hemilabile participation to facilitate catalytic steps. With N-arylpyrroles (L3-L5), where the second nitrogen donor on the heterocycle is absent, coupling reactions of unactivated chloroarenes still proceeded with comparable efficiency. Thus, suitably endowed triarylphosphines were found to be as efficient as more expensive aryldialkylphosphine analogs in reactions with chloroarenes, extending the scope of ligand design.

Steric vis-??-vis electronic influence of phosphines on biaryl motif: Ligand design for coupling reactions with Chloroarenes

In order to assess relative contribution of steric factors and electron-richness of phosphine ligands on biaryl-type scaffolds, a set of 1-aryl-pyrazole/pyrrole derived ligands L1-L6 featuring either aryldicyclohexylphosphino or aryldiphenylphosphino donor group was synthesized. A bidentate coordination mode of ligands L1 or L2 was evident from a representative crystal structure that implied a possible hemilabile participation to facilitate catalytic steps. With N-arylpyrroles (L3-L5), where the second nitrogen donor on the heterocycle is absent, coupling reactions of unactivated chloroarenes still proceeded with comparable efficiency. Thus, suitably endowed triarylphosphines were found to be as efficient as more expensive aryldialkylphosphine analogs in reactions with chloroarenes, extending the scope of ligand design.

Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase

Structure-activity relationships have been investigated for inhibition of DNA-dependent protein kinase (DNA-PK) and ATM kinase by a series of pyran-2-ones, pyran-4-ones, thiopyran-4-ones, and pyridin-4-ones. A wide range of IC50 values were observed for pyranones and thiopyranones substituted at the 6-position, with the 3- and 5-positions proving intolerant to substitution. Related pyran-2-ones, pyran-4-ones, and thiopyran-4-ones showed similar IC50 values against DNA-PK, whereas the pyridin-4-one system proved, in general, ineffective at inhibiting DNA-PK. Extended libraries exploring the 6-position of 2-morpholinopyran-4-ones and 2-morpholino- thiopyrano-4-ones identified the first highly potent and selective ATM inhibitor 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one (151C; ATM; IC50 = 13 nM) and revealed constrained SARs for ATM inhibition compared with DNA-PK. One of the most potent DNA-PK inhibitors identified, 2-(4-methoxyphenyl)-6- (morpholin-4-yl)pyran-4-one (16; DNA-PK; IC50 = 220 nM) effectively sensitized HeLa cells to the topoisomerase II inhibitor etoposide in vitro.

PROCESSES FOR PREPARING β-DIKETONE COMPOUND, METAL COMPLEX THEREOF AND METALLIC COMPOUND

Disclosed is a process for preparing a β-diketone compound such as 2,6-dimethyl-3,5-heptanedione, which comprises reacting an ester compound such as an alkyl isobutyrate with a ketone compound such as 3-methylbutanone in the presence of an alkali metal alkoxide as a catalyst. The process comprises a step 1 in which an ester compound CR1R2R3COOQ is reacted with a ketone compound CR4R5R6COCH2R7 using an alkali metal alkoxide catalyst to give a β-diketone compound CR1R2R3COCHR4R5R6. (In the formulae, R7 is hydrogen or an alkyl group of 1 to 4 carbon atoms while others are each independently hydrogen or an alkyl group of 1 to 3 carbon atoms, and at least one of R1 to R6 is hydrogen.)

Semi-synthetic C23-substituted milbemycins via spiroacetal cleavage and resynthesis

The lactone intermediates (2) and (3) are converted by lithium acetylide chemistry followed by mercury catalysed hydration to novel semi-synthetic 23-oxo C24 and C25 substituted milbemycins (7).

CONDENSATION OF NITRILES WITH METHYL KETONES AS A METHOD FOR THE SYNTHESIS OF β-AMINOVINYL KETONES

The condensation of nitriles containing aromatic substituents and of trichloroacetonitrile with methyl ketones in the presence of (phenylethylamino)magnesium bromide leads to β-aminovinyl ketones.Acid hydrolysis of the β-aminovinyl ketones gave high yields of the corresponding β-diketones.

The Crystallographic Characterization of an Unusual Chemical Reversal of Photoisomerization

Imines formed from pinacolone and primary amines could be acylated by acid chlorides or anhydrides to products hydrolysable to 1,3-diones.Benzoyl chloride with pinacolone benzylimine gave 3-(N-benzoyl-N-benzylamino)-4,4-dimethyl-1-phenylpent-2-en-1-one, both geometrical isomers of which were prepared.The yellow Z isomer was converted into the colourless E isomer on exposure to daylight and this change was reversed by brief treatment of the E isomer with aqueous ethanolic alkali.The Z and E isomers have been characterized crystallographically.The E isomer is monoclinic, C2/c, a 10.241(4), b 17.199(6), c 25.495(9) Angstroem, β 100.45(3) deg, Z = 8; R was 0.052 for 1947 'observed reflections.The Z-isomer is orthorhombic, P212121, a 18.24(1), b 15.60(1), c 7.871(4) Angstroem, Z = 4; R was 0.61 for 902 'observed' reflections.