5828-69-3Relevant academic research and scientific papers
Phosphorous acid-catalyzed alkylation of phenols with alkenes
Wu, Shaofeng,Dong, Jianyu,Zhou, Dan,Wang, Wan,Liu, Long,Zhou, Yongbo
, p. 14307 - 14314 (2020)
A H3PO3-catalyzed alkylation of phenols with alkenes is achieved in a facile, efficient, and selective manner. The reaction shows a unique selectivity, i.e., excellent regioselectivity, thorough suppression of overalkylation, without alkylation of a simple phenyl ring, and can selectively provide ortho-, meta-, or para-alkylated phenol derivatives in good to excellent yields. This feature along with mild reaction conditions, sensitive functional group tolerance, and scale-up synthesis and late modification of phenolic bioactive compounds make it an ideal and practical alternative for the modification of phenols.
Preparation method of alkylphenol compounds
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Paragraph 0061-0063, (2020/04/29)
The invention provides a method for preparing alkylphenol compounds from phenol compounds and olefin. The method has the characteristics of cheap and easily available raw materials, simple reaction system, simplicity in reaction operation, wide substrate range, compatibility with groups such as CHO and COOH, and excellent regioselectivity, generates no overalkylation products due to only alkylation of phenol and no influence on common aryl groups, and can be used for modifying drug intermediates. The method mainly solves the problems of harsh conditions such as use of a strong Lewis catalyst,poor functional group compatibility, poor selectivity, need of prefabrication of a catalyst material and the like in other methods, and H3PO3 plays a dual role in the same system, can promote alkene to generate carbocations, and also can inhibit isomerization of phenol.
