583027-32-1

Basic information

• Product Name: 5-oxo-5-phenyl-pentanoic acid 2,4-dimethoxy-benzylamide
• Synonyms: 5-oxo-5-phenyl-pentanoic acid 2,4-dimethoxy-benzylamide
• CAS NO: 583027-32-1
• Molecular Weight: 341.407
• Mol File: 583027-32-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-oxo-5-phenyl-pentanoic acid 2,4-dimethoxy-benzylamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-oxo-5-phenyl-pentanoic acid 2,4-dimethoxy-benzylamide(583027-32-1)
• EPA Substance Registry System: 5-oxo-5-phenyl-pentanoic acid 2,4-dimethoxy-benzylamide(583027-32-1)

Safety Data

• Hazardous Substances Data: 583027-32-1(Hazardous Substances Data)

Downstream Products

• 91132-81-9 5-oxo-5-phenyl-valeric acid amide 
• 34502-63-1 6-Phenyl-1,2,3,4-tetrahydropyridin-2-on 

Relevant articles and documents

Selective N-debenzylation of amides with p-TsOH

N-Benzylamides were debenzylated efficiently with 4 equiv. of p-TsOH in refluxing toluene. Good to quantitative yields of the desired primary amides were obtained within 2-4 h from a wide variety of N-2,4-dimethoxybenzylamides. N-4-Methoxylbenzyl amides and N-benzylamides were also debenzylated cleanly. In the case of N-2,4-dimethoxylbenzylamides, selective N-debenzylation was possible in the presence of N-Fmoc, N-t-BOC or N-trityl-protection. Protected amino acid amides survived these conditions without any detectable epimerization.