91132-81-9

Basic information

• Product Name: 5-oxo-5-phenyl-valeric acid amide
• Synonyms: 5-oxo-5-phenyl-valeric acid amide
• CAS NO: 91132-81-9
• Molecular Weight: 191.23
• Mol File: 91132-81-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-oxo-5-phenyl-valeric acid amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-oxo-5-phenyl-valeric acid amide(91132-81-9)
• EPA Substance Registry System: 5-oxo-5-phenyl-valeric acid amide(91132-81-9)

Safety Data

• Hazardous Substances Data: 91132-81-9(Hazardous Substances Data)

Upstream product

• 4055-00-9 6-phenyl-3,4-dihydropyran-2-one 
• 1198-34-1 2-Phenylcyclopentanone 
• 83849-01-8 2-phenylcyclopentan-1-one oxime 
• 108-86-1 bromobenzene 
• 120-92-3 cyclopentanone 
• 36603-28-8 5-phenylpentanitrile 
• 583027-32-1 5-oxo-5-phenyl-pentanoic acid 2,4-dimethoxy-benzylamide 
• 10413-00-0 5-oxo-5-phenylpentanenitrile 
• 1501-05-9 5-oxo-5-phenylvaleric acid 
• 1121-89-7 piperidine-2,6-dione 
• 591-51-5 phenyllithium 
• 1501-04-8 Methyl 4-benzoylbutanoate 

Downstream Products

• 169601-97-2 4-(3,6-dihydro-4-hydroxy-6-oxo-2-phenyl-2H-pyran-2-yl)butyramide 
• 104850-13-7 5-phenyl-5-semicarbazono-valeronitrile 
• 18214-22-7 5-(2,4-dinitro-phenylhydrazono)-5-phenyl-valeronitrile 
• 19006-82-7 2-hydroxy-6-phenylpyridine 
• 34502-63-1 6-Phenyl-1,2,3,4-tetrahydropyridin-2-on 
• 10413-00-0 5-oxo-5-phenylpentanenitrile 

Relevant articles and documents

Photoinduced C—C Bond Cleavage and Oxidation of Cycloketoxime Esters

A novel structural reorganization of cycloketoxime esters beyond the traditional Beckmann rearrangement process has been established to build cyano-containing ketones in the presence of photocatalyst. This novel transformation is remarkable with selective C—C bond cleavage and an oxidation process enabled by DMSO used as the solvent, oxidant, and oxygen source avoiding acid, base and toxic cyanide salts as the cyano source. Further applications in late-stage modification of complex and chiral molecules have also been reported.

Selective N-debenzylation of amides with p-TsOH

N-Benzylamides were debenzylated efficiently with 4 equiv. of p-TsOH in refluxing toluene. Good to quantitative yields of the desired primary amides were obtained within 2-4 h from a wide variety of N-2,4-dimethoxybenzylamides. N-4-Methoxylbenzyl amides and N-benzylamides were also debenzylated cleanly. In the case of N-2,4-dimethoxylbenzylamides, selective N-debenzylation was possible in the presence of N-Fmoc, N-t-BOC or N-trityl-protection. Protected amino acid amides survived these conditions without any detectable epimerization.

Synthesis of 6-Hydroxy-3,4,5,6-tetrahydro-2-pyridones and 3,4-Dihydro-2-pyridones by H2O2/DMSO Hydration of δ-Ketonitriles

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