583045-88-9Relevant academic research and scientific papers
Studies towards the identification of a new generation of atypical antipsychotic agents
Garzya, Vincenzo,Forbes, Ian T.,Gribble, Andrew D.,Hadley, Mike S.,Lightfoot, Andrew P.,Payne, Andrew H.,Smith, Alexander B.,Douglas, Sara E.,Cooper, David G.,Stansfield, Ian G.,Meeson, Malcom,Dodds, Emma E.,Jones, Declan N.C.,Wood, Martyn,Reavill, Charlie,Scorer, Carol A.,Worby, Angela,Riley, Graham,Eddershaw, Peter,Ioannou, Chris,Donati, Daniele,Hagan, Jim J.,Ratti, Emiliangelo A.
, p. 400 - 405 (2007/10/03)
A rational structure-activity relationship study around compound (1) is reported. The lead optimisation programme led to the identification of sulfonamide (25), a molecule combining dopamine D2/D3 receptor antagonism with serotonin 5
