77474-50-1

Basic information

• Product Name: 1-[(2'-HYDROXYETHOXY)-METHYL]-5-FLUOROURACIL
• Synonyms: 5-fluoro-1-((2-hydroxyethoxy)methyl)uracil;1-[(2'-HYDROXYETHOXY)-METHYL]-5-FLUOROURACIL
• CAS NO: 77474-50-1
• Molecular Formula: C₇H₉FN₂O₄
• Molecular Weight: 204.16
• Mol File: 77474-50-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Density: 1.49g/cm³
• Refractive Index: 1.544
• CAS DataBase Reference: 1-[(2'-HYDROXYETHOXY)-METHYL]-5-FLUOROURACIL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2'-HYDROXYETHOXY)-METHYL]-5-FLUOROURACIL(77474-50-1)
• EPA Substance Registry System: 1-[(2'-HYDROXYETHOXY)-METHYL]-5-FLUOROURACIL(77474-50-1)

Safety Data

• Hazardous Substances Data: 77474-50-1(Hazardous Substances Data)

Usage

Chemical class

Pyrimidine analog

Parent compound

5-fluorouracil

Antineoplastic activity

Inhibits thymidylate synthase, disrupts DNA synthesis

Antiangiogenic activity

Potential to inhibit the formation of new blood vessels in tumors

Modification

Addition of 2'-hydroxyethoxy methyl group

Solubility

Enhanced by the 2'-hydroxyethoxy methyl group

Tumor cell penetration

Improved due to increased solubility

Stability

Increased by the 2'-hydroxyethoxy methyl group, prolonging half-life in the body

Preclinical studies

Shown promise in the treatment of various types of cancer

Ongoing research

Further evaluation of its potential as a therapeutic agent for cancer treatment

InChI:InChI=1/C7H9FN2O4/c8-5-3-10(4-14-2-1-11)7(13)9-6(5)12/h3,11H,1-2,4H2,(H,9,12,13)

Upstream product

• 40510-88-1 1-acetoxy-2-chloromethoxyethane 
• 51-21-8 5-fluorouracil 
• 78692-72-5 1-<(2-acetoxyethoxy)methyl>-5-fluoro-4-(methylthio)pyrimidin-2(1H)-one 
• 78137-60-7 Benzoic acid 2-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethoxy)-ethyl ester 
• 78692-75-8 5-fluoro-1-[(2-hydroxyethoxy)methyl]cytosine 
• 80504-48-9 1,2-dihydro-5-fluoro-4-methoxy-2-oxo-1-(2'-benzoyloxyethoxymethyl)pyrimidine 
• 77474-49-8 1-<(2-acetoxyethoxy)methyl>-5-fluorouracil 
• 58305-05-8 (2-benzoyloxyethyl)oxymethyl chloride 
• 51-21-8 5-fluorouracil 
• 646-06-0 1,3-DIOXOLANE 
• 17242-85-2 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine 

Downstream Products

• 136632-04-7 1-<(2-hydroxyethoxy)methyl>-6-(phenylselenenyl)-5-fluorouracil 
• 136631-98-6 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylselenenyl)-5-fluorouracil 
• 123027-53-2 5-Fluoro-1-(2-hydroxy-ethoxymethyl)-6-phenylsulfanyl-1H-pyrimidine-2,4-dione 
• 123027-48-5 1-[2-(tert-Butyl-dimethyl-silanyloxy)-ethoxymethyl]-5-fluoro-6-phenylsulfanyl-1H-pyrimidine-2,4-dione 
• 77474-49-8 1-<(2-acetoxyethoxy)methyl>-5-fluorouracil 

Relevant articles and documents

Bisphosphonate conjugates and methods of making and using the same

The present invention is directed to particular bisphosphonate compounds, and in particular, to bisphosphonate conjugates that are useful in the treatment of soft tissues surrounding bone and bone-related diseases, such as bone cancer and osteoporosis.

A facile synthetic method for pyrimidine acyclonucleoside derivatives

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Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same

Novel uracil derivatives of the formula STR1 (wherein R1, R2 R3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.