58311-53-8

Usage

Uses

Used in Pharmaceutical Industry:
(S)-3,4-Dimethyloxazolidine-2,5-dione is used as a key intermediate in the synthesis of various pharmaceutical compounds for its unique stereochemistry and reactivity. This allows for the development of new drugs with specific therapeutic properties.
Used in Materials Science:
(S)-3,4-Dimethyloxazolidine-2,5-dione is used as a building block in the creation of novel materials with potential applications in various industries, such as plastics, coatings, and adhesives, due to its structural properties and ability to form stable compounds.
Used in Biochemical Research:
(S)-3,4-Dimethyloxazolidine-2,5-dione is used as a research tool in biochemical studies to understand the mechanisms of various biological processes and to develop new methods for synthesizing complex molecules.
As with most chemicals, proper handling and safety measures are necessary, but further research into its potential uses and benefits remains ongoing.

Upstream product

• 1085528-19-3 2-(methoxycarbonylmethylamino)propionic acid 
• 3913-67-5 N-methylalanine 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 
• 530-62-1 1,1'-carbonyldiimidazole 
• 16948-16-6 N-(tert-butoxycarbonyl)-N-methyl-L-alanine 

Relevant academic research and scientific papers

Synthesis of α-Amino Acid N-Carboxyanhydrides

A simple phosgene- and halogen-free method for synthesizing α-amino acid N-carboxyanhydrides (NCAs) is described. The reaction between Boc-protected α-amino acids and T3P reagent gave the corresponding NCA derivatives in good yield and purity with no detectable epimerization. The process is safe, is easy-to-operate, and does not require any specific installation. It generates nontoxic, easy to remove byproducts. It can apply to the preparation of NCAs for the on-demand on-site production of either little or large quantities.

NOVEL CONNECTED BODY AND USE THEREOF IN SPECIFIC CONJUGATION BETWEEN BIOMOLECULE AND DRUG

PROBLEM TO BE SOLVED: To provide: a method for producing a connected body; a method for using the connected body in the production of a uniform conjugate; and a method for applying the conjugate in the treatment of cancer, infectious diseases, and autoimmune diseases. SOLUTION: A novel connected body is provided that includes a 2,3-di-substituted succinic acid group or a 2-mono-substituted or 2,3-di-substituted fumaric acid or maleic acid (trans (E)- or cis (Z)-butenedioic acid) group for conjugating 2 or more compounds/cytotoxic agents per connected body with a cell-binding molecule by specifically bridge-linking to a pair of thiol on the cell-binding molecule. The connected body is exemplified by the following general formula. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS

Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.

METHOD FOR PREPARATION OF N-CARBOXYANHYDRIDES

The invention discloses a method for the preparation off N-carboxyanhydrides (NCAs) by reaction of amino acids with phosgene.(II)

ANTI-CD22 ANTIBODY-MAYTANSINE CONJUGATES, COMBINATIONS, AND METHODS OF USE THEREOF

The present disclosure provides methods for treating a cancer or resistant cancer with a combination of an anti-CD22 antibody-maytansine conjugate and one or more anti-cancer agents. The disclosure also encompasses methods for sensitizing a cancer with such combinations. Also provided are pharmaceutical compositions including such combinations.

ANTI-CD22 ANTIBODY-MAYTANSINE CONJUGATES AND METHODS OF USE THEREOF

The present disclosure provides anti-CD22 antibody-maytansine conjugate structures. The disclosure also encompasses methods of production of such conjugates, as well as methods of using the same.

METHOD FOR PREPARING ENANTIOMERICALLY ENRICHED N-CARBOXYANHYDRIDE

This disclosure relates to methods for preparing an enantiomerically enriched N-carboxyanhydride of an amino alpha acid of the formula (IIIa) or (IIIb): from a compound of the formula (IIa) or (IIb), respectively: wherein R1, R2, and R3 are as defined in the disclosure.

Method for the preparation of maytansinoid esters

Improved processes for the preparation and purification of maytansinoid esters, especially thiol and disulfide-containing maytansinoids are described. In one aspect the process comprises a process of making a maytansinoid ester comprising forming an anion of maytansinol or a maytansinoid bearing a free C-3 hydroxyl moiety and reacting the anion with an activated carboxyl compound to thereby produce the maytansinoid ester.

New routes to 1,4-benzodiazepin-2,5-diones

1,4-benzodiazepin-2,5-diones have been synthesized in good overall yields by two routes, the first one by cyclisation of dipeptides prepared from Boc anthranilic acid and α-amino acid methyl esters, the second one by reaction of N-carboxy α-amino acid anhydrides with Boc anthranilic acid.