58325-18-1

Usage

Uses

Used in Organic Synthesis Industry:
(2,2-difluoropropyl)benzene is used as a solvent for various organic reactions, facilitating the process and improving the yield of desired products. Its unique chemical properties, such as its difluoropropyl groups, make it a valuable intermediate in the synthesis of more complex organic compounds.
Used in Chemical Intermediates:
(2,2-difluoropropyl)benzene serves as a key intermediate in the production of various specialty chemicals, including pharmaceuticals, agrochemicals, and other fine chemicals. Its ability to participate in a wide range of chemical reactions makes it a versatile building block for the synthesis of target molecules.
Used in Raw Material Production:
As a raw material, (2,2-difluoropropyl)benzene is utilized in the manufacturing of various industrial products, such as polymers, coatings, and adhesives. Its unique properties, including its difluoropropyl groups, contribute to the performance characteristics of the final products, enhancing their properties and applications.

Upstream product

• 29443-57-0 1-phenyl-2,2-diiodopropane 
• 103-79-7 1-phenyl-acetone 
• 34917-00-5 2-benzyl-2-methylmalonic acid 
• 5171-99-3 (1-phenylpropan-2-ylidene)hydrazine 
• 133932-46-4 (2,2-Difluoro-1-iodo-propyl)-benzene 
• 133932-45-3 (2,2-Difluoro-3-iodo-propyl)-benzene 
• 16602-83-8 phenyl-acetone-methylhydrazone 
• 13099-51-9 2,2-Dichlor-1-phenyl-propan 
• 13343-40-3 (2,2-difluoro-1-cyclopropyl)benzene 
• 98-83-9 isopropenylbenzene 

Relevant academic research and scientific papers

Ag-Catalyzed Chemoselective Decarboxylative Mono- and gem-Difluorination of Malonic Acid Derivatives

Malonic acid derivatives have been successfully applied in a Ag-catalyzed decarboxylative fluorination reaction, providing an unprecedented route to either gem-difluoroalkanes or α-fluorocarboxylic acids by the judicious selection of base and solvent. This reaction features the use of readily available starting materials, tunable chemoselectivity and good functional group compatibility as well as gram-scale synthetic capability. The advantage of using malonic acid derivatives in this radical decarboxylative functionalization is further highlighted by the facile transformations of the α-fluorocarboxylic acid to valuable fluorine-containing compounds. Preliminary mechanistic studies suggest that an α-carboxylic acid radical is involved in this reaction.

Ag-Catalyzed Chemoselective Decarboxylative Mono- and gem-Difluorination of Malonic Acid Derivatives

Malonic acid derivatives have been successfully applied in a Ag-catalyzed decarboxylative fluorination reaction, providing an unprecedented route to either gem-difluoroalkanes or α-fluorocarboxylic acids by the judicious selection of base and solvent. This reaction features the use of readily available starting materials, tunable chemoselectivity and good functional group compatibility as well as gram-scale synthetic capability. The advantage of using malonic acid derivatives in this radical decarboxylative functionalization is further highlighted by the facile transformations of the α-fluorocarboxylic acid to valuable fluorine-containing compounds. Preliminary mechanistic studies suggest that an α-carboxylic acid radical is involved in this reaction.

Synthetic method of difluoromethyl compound

The invention discloses a synthetic method of a difluoromethyl compound. The synthetic method of the difluoromethyl compound comprises the following steps: selecting styrene derivatives as raw materials, selecting dichloromethane as a solvent and triethylamine trihydrofluoride as a fluorinating agent and carrying out sufficient reaction at the temperature of 70 to 90 DEG C in the presence of a hypervalent iodine reagent iodobenzene diacetate; after the reaction is ended, separating and purifying reaction liquid to obtain the difluoromethyl compound. The synthetic method disclosed by the invention has the advantages of reasonable process conditions, simple operation, short reaction time, stable conversion rate and yield and wide substrate range. By adopting the triethylamine trihydrofluoride as the fluorinating agent, convenience in treatment is realized and no metal catalyst is needed, so the synthetic method is a high-efficiency synthetic method for synthesizing the difluoromethyl.

Hypervalent Iodine-Mediated Fluorination of Styrene Derivatives: Stoichiometric and Catalytic Transformation to 2,2-Difluoroethylarenes

Fluorination of styrene derivatives with a reagent system composed of μ-oxo-bis[trifluoroacetato(phenyl)iodine] and a pyridine·HF complex gave the corresponding (2,2-difluoroethyl)arenes in good yields. Similarly, the reagent of PhI(OCOCF3)2 and the pyridine·HF complex acted as a fluorinating agent for styrene derivatives. The fluorination of styrene derivatives with the pyridine·HF complex underwent under catalytic conditions using 4-iodotoluene as a catalyst and m-CPBA as a terminal oxidant.

Fluorination reactions in microreactors

The DAST-mediated conversion of a range of alcohols to the corresponding fluorides in a microstructured device is described. This safe, practical fluorination method will facilitate reactions currently challenging on large scale. The Royal Society of Chem

Conversion of the Carbonyl Group to CF2 Using IF

A novel method for the transformation of CO -> CF2 is described.The easily made hydrazone derivatives of the carbonyl moiety are reacted under mild conditions with IF prepared directly from the corresponding elements.Various hydrazones have been examined and compared with each other.Unsubstituted ones are usually the most suitable although they are not always easy to purify and store.N-Methyl- and N,N-dimethylhydrazones also give quite satisfactory results.The more easily made dinitrophenyl hydrazones (DNPs), semicarbazones, and tosylhydrazones also react, but the yields of the desired CF2 compounds are usually lower.Oximes could also be successfully reacted.The two main byproducts of the reaction are the parent carbonyl compounds, which can be recycled, and the α-iododifluoro derivatives.The latter upon treatment with LiAlH4 or Bu3SnH were reduced to the desired product, thus increasing the overall yields.

A MILD, CONVENIENT, HALOGEN-EXCHANGE ROUTE TO GEM-DIFLUORIDES AND TRIFLUORIDES

Reaction of gem-dihalides R1R2CX2 (X=Cl or I) and of PhCCl3 with AgBF4 at room or sub-ambient temperatures affords the corresponding gem-difluorides and trifluoride in unoptimised yields of 35-84percent.

CATALYTIC HYDROGENOLYSIS OF 1,1-DIFLUORO-2-PHENYL-AND 1,1-DIFLUORO-3-METHYL-2-PHENYLCYCLOPROPANE.

The title compounds were hydrogenolyzed over PdO or Raney nickel. The C//2-C//3 bond of the cyclopropane ring underwent cleavage exclusively over both catalyts. The contribution of the fluorine substituent to the lengthening and weakening the C//2-C//3 bond of the cyclopropane ring seems to become a dominant factor in regioselectivity.