34917-00-5

Upstream product

• 55114-30-2 2-benzyl-2-methylmalonic acid diethyl ester 
• 95929-64-9 benzylmethylpropanedioic acid dimethyl ester 
• 100-44-7 benzyl chloride 
• 609-08-5 Diethyl methylmalonate 

Downstream Products

• 95929-64-9 benzylmethylpropanedioic acid dimethyl ester 
• 17496-14-9 2,3-dihydro-2-methyl-1H-inden-1-one 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 117749-63-0 2-benzoyl-2-methyl-indan-1-one 
• 1009-67-2 2-methyl-3-phenylpropionic acid 
• 861355-80-8 2-benzyl-2-methylmalonyl dichloride 
• 124-38-9 carbon dioxide 
• 220325-81-5 5-benzyl-1,3,5-trimethyl-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 220325-64-4 5-benzyl-1,3,5-trimethyl-pyrimidine-2,4,6-trithione 
• 220325-70-2 C₂₈H₃₀N₄S₄ 
• 29393-16-6 methyl 2-methyl-3-phenylpropionate 
• 183676-97-3 α-benzyl-α-methylmalonamide 
• 7384-80-7 (S)-2-methyl-3-phenylpropan-1-ol 
• 22436-06-2 2-methyl-3-phenylpropanol 

Relevant academic research and scientific papers

Design of bisquinolinyl malonamides as Zn2+ ion-selective fluoroionophores based on the substituent effect

A series of malonamides possessing two quinoline moieties were synthesized and characterized as fluoroionophores for the Zn2+ ion. We focused on the relationship between the substituents introduced to the C2-position of the malonamides and their Zn2+ ion-selectivity, exploiting the structural effect of the substituents in the design of the fluoroionophores with high selectivity. The substituents introduced to the malonamides were the methyl, benzyl and naphthalenylmethyl groups. In dimethyl sulfoxide solvent, all substituted bisquinolinyl malonamides showed excellent fluorescence sensing for the Zn2+ ion, while unsubstituted bisquinolinyl malonamide 1 displayed ratiometric sensing for the Co2+ ion. N,N′-Bis(8-quinolyl)-2-methyl-2-naphthalenylmethyl malonamide 4 exhibited the highest Zn2+ ion-selectivity against the Cd2+ ion. Although the substituents introduced into the C2-position are spatially distant from the quinoline recognition moiety, this study indicated that they greatly influenced the ion selectivities of the bisquinolinyl malonamides. Furthermore, it was demonstrated that visible fluorescence analyses could be performed on malonamide 4.

Gas-phase pyrolytic reaction of 3-phenoxy and 3-phenylsulfanyl-1-propanol derivatives: Kinetic and mechanistic study

3-Phenoxy-l-propanols 1a-c and 3-phenylsuIfanyl-1-propanols 2a-c containing primary, secondary, and tertiary alcohols were prepared and subjected to gas-phase pyrolysis in a static reaction system. Pyrolysis of 4-phenyl-1-butanol 3, 2-methyl-3-phenyl-1-propanol 4, and 2-methyl-3-phenylpropanoic acid 5 was also studied, and results were compared with those obtained for compounds 1-3. The pyrolytic reactions were homogeneous and followed a first-order rate equation. Analysis of the pyrolysate showed the products to be phenol (from la to 1c), thiophenol (from 2a to 2c), and toluene (from 3 to 5) and carbonyl compounds. The kinetic results and product analysis of each of the nine investigated compounds are rationalized in terms of a plausible transition state for the elimination pathway.

Indene-based scaffolds. Design and synthesis of novel serotonin 5-HT 6 receptor ligands

A series of novel indene derivatives designed by a scaffold selection gave access to several examples of (Z)-arylmethylideneindenes and indenylsulfonamides that acted as serotonin 5-HT6 receptor ligands. Different synthetic multistep routes could be applied to these target compounds, each with their own complexity and limitations. A reasonable route involved the (3-indenyl)acetic acids as the key intermediates, and two alternatives were also examined. The first protocol used was a two-step sequence employing a modified Horner-Wadsworth-Emmons reaction, but better results were obtained with a procedure based on the condensation of indanones with the lithium salt of ethyl acetate, followed immediately by dehydration with acid and hydrolysis/ isomerization under basic catalysis. (3-Indenyl)acetic acids were transformed to the corresponding acetamides, which were effectively reduced to indenylsulfonamides 13-17 using an optimized procedure with AlH 3-NMe2Et. The binding at the 5-HT6 receptor was with moderate affinity (Ki = 216.5 nM) for the (Z)- benzylideneindenylsulfonamide 12 and enhanced affinity for the simple indenylsulfonamide counterpart 13 (Ki = 50.6 nM). Selected indenylsulfonamides 14-17 were then tested, showing Ki values as low as 20.2 nM. The Royal Society of Chemistry 2008.

XANTHINE DERIVATIVES AS ADENOSINE A1 RECEPTOR ANTAGONISTS

A method of attenuating a cognitive deficit in a patient in need thereof comprising administering to the patient a xanthine derivative.

The application of 1H nuclear magnetic resonance spectroscopy for the determination of the absolute configuration of chiral carboxylic acids

A modification of a model, described by Mosher allows a correlation to be made between the absolute configuration of a range of simple chiral carboxylic acids with the corresponding nmr chemical shifts of their esters derived from (S)-methyl mandelate.

Selective adenosine receptor agents

Xanthine derivative which act selectively at adenosine receptors and which act in general as adenosine antagonists are disclosed. From in vitro studies it is known that specific physiological effects can be distinguished as a result of this selectively and that adenosine receptor activity in vitro correlates with adenosine receptor activity in vivo.Pharmaceutical preparations of the subject compounds can be prepared on the basis of the selective binding activity of the compounds disclosed herein which will enhance certain physiological effects while minimizing others, such as decreasing blood pressure without decreasing heart rate.

CHEMOENZYMATIC SYNTHESIS OF THE ENANTIOMERS OF IOPANOIC ACID

The two enantiomers of Iopanoic acid 1 were prepared in enantiomeric excess higher than 90percent by enzyme-catalyzed hydrolysis of precursors (+/-)-2a and (+/-)-3a, followed by standard chemical transformations.Among the tested enzymes, chymotrypsin and Lipase PS proved to be the most selective catalysts.The stereochemical outcome of the lipase-catalyzed hydrolyses of esters (+/-)-2a-d is strictly dependent upon both the size of the alkyl group attached to the chiral center and the substituent in the aromatic ring.The enantioselectivity of the reactions was evaluated by chiral HPLC and the configurations of the new products were assigned by chemical correlations.