58327-38-1Relevant academic research and scientific papers
Some derivatives of 2,4 diamino 5 phenylthiazole (amiphenazole)
Adams,Nicholls,Williams
, p. 425 - 427 (2007/10/05)
To facilitate metabolic studies on the analeptic 2,4 diamino 5 phenylthiazole (Amiphenazole) attempts were made to synthesise 2,4 diamino 5 (p hydroxyphenyl) thiazole (unsuccessful) and 2,4 dihydroxy 5 (p hydroxyphenyl) thiazole (successful) as possible metabolites. The pharmacology of some synthetic intermediates revealed that 2,4 diamino 5 (p methoxyphenyl) thiazole was a more potent stimulant than Amiphenazole in morphine depressed respiration of rabbits whilst therapeutic indices were comparable. 2,4 Diamino 5 (p benzyloxyphenyl) thiazole depressed locomotor activity in mice. 2,4 Dihydroxy 5 (p hydroxyphenyl) thiazole did not affect morphine induced analgesia in mice.
