58327-37-0

Basic information

• Product Name: α-Chloro-α-(4-methoxyphenyl)acetonitrile
• Synonyms: α-Chloro-α-(4-methoxyphenyl)acetonitrile
• CAS NO: 58327-37-0
• Molecular Weight: 181.622
• Mol File: 58327-37-0.mol

Chemical Properties

• CAS DataBase Reference: α-Chloro-α-(4-methoxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α-Chloro-α-(4-methoxyphenyl)acetonitrile(58327-37-0)
• EPA Substance Registry System: α-Chloro-α-(4-methoxyphenyl)acetonitrile(58327-37-0)

Safety Data

• Hazardous Substances Data: 58327-37-0(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 123-11-5 4-methoxy-benzaldehyde 
• 33646-40-1 4-methoxymandelonitrile 

Downstream Products

• 117828-32-7 4,6-dihydroxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 
• 145622-39-5 4,6-Dihydroxy-3-(4-methoxy-phenyl)-3H-benzofuran-2-one 
• 95-94-3 1,2,4,5-tetrachlorobenzene 
• 6476-61-5 trans-1,2-Dicyano-1,2-bis(4-methoxyphenyl)ethylene 
• 111243-95-9 3-Butyl-2-(2-[1,3]dithian-2-yl-1-phenyl-ethyl)-4,6-dimethoxy-2-(4-methoxy-phenyl)-2,3-dihydro-benzofuran-3-ol 
• 111222-89-0 3-(2-[1,3]Dithian-2-yl-1-phenyl-ethoxy)-4,6-dimethoxy-2-(4-methoxy-phenyl)-benzofuran 
• 111222-93-6 2-hydroxy-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 
• 111222-90-3 2-<2-(1,3-dithian-2-yl)-1-phenylethyl>-4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 
• 136850-29-8 3-<4,6-dimethoxy-2-(4-methoxyphenyl)-3-oxo-2,3-dihydrobenzofuran-2-yl>-3-phenylpropanal 
• 117828-33-8 4,6-dimethoxy-2-(4-methoxyphenyl)benzofuran-3(2H)-one 
• 58327-38-1 5-(4-methoxy-phenyl)-thiazole-2,4-diamine 

Relevant articles and documents

Development of a catalytic platform for nucleophilic substitution: Cyclopropenone-catalyzed chlorodehydration of alcohols

Cyclopropenone makes the switch: 2,3-Bis-(p-methoxyphenyl)cyclopropenone is a highly efficient catalyst for the chlorodehydration of 20 diverse alcohol substrates (see scheme; X=Cl). With oxalyl chloride as catalytic activator, this nucleophilic substitution proceeded through cyclopropenium-activated intermediates and resulted in complete stereochemical inversion in substrates with chiral centers.

ONE-POT SYNTHESIS OF α-CHLORONITRILES FROM ARYLCARBONYL COMPOUNDS

α-Chloronitriles are prepared by the reaction of arylcarbonyl compounds and trimethylsilyl cyanide with a stoichiometric amount of titanium tetrachloride in good yields.

Some derivatives of 2,4 diamino 5 phenylthiazole (amiphenazole)

To facilitate metabolic studies on the analeptic 2,4 diamino 5 phenylthiazole (Amiphenazole) attempts were made to synthesise 2,4 diamino 5 (p hydroxyphenyl) thiazole (unsuccessful) and 2,4 dihydroxy 5 (p hydroxyphenyl) thiazole (successful) as possible metabolites. The pharmacology of some synthetic intermediates revealed that 2,4 diamino 5 (p methoxyphenyl) thiazole was a more potent stimulant than Amiphenazole in morphine depressed respiration of rabbits whilst therapeutic indices were comparable. 2,4 Diamino 5 (p benzyloxyphenyl) thiazole depressed locomotor activity in mice. 2,4 Dihydroxy 5 (p hydroxyphenyl) thiazole did not affect morphine induced analgesia in mice.