58327-76-7

Basic information

• Product Name: 3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
• Synonyms: 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylic acid(SALTDATA: FREE);Thieno[2,3-b]pyridine-2-carboxylicacid, 3-aMino-4,6-diMethyl-;3-amino-4,6-dimethyl-2-thieno[5,4-b]pyridinecarboxylic acid;3-amino-4,6-dimethyl-thieno[5,4-b]pyridine-2-carboxylic acid;3-amino-4,6-dimethylthieno[5,4-b]pyridine-2-carboxylic acid;3-Amino-4,6-dimethylthieno[2,3-b]pyridin-2-carboxylic acid
• CAS NO: 58327-76-7
• Molecular Formula: C₁₀H₁₀N₂O₂S
• Molecular Weight: 222.27
• Mol File: 58327-76-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 158 °C (decomp)
• Boiling Point: 450.2 °C at 760 mmHg
• Flash Point: 226.1 °C
• Appearance: /
• Density: 1.446 g/cm³
• Vapor Pressure: 6.85E-09mmHg at 25°C
• Refractive Index: 1.731
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.24±0.30(Predicted)
• CAS DataBase Reference: 3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID(58327-76-7)
• EPA Substance Registry System: 3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID(58327-76-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 58327-76-7(Hazardous Substances Data)

Usage

General Description

3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID is a chemical compound with the molecular formula C11H11N3O2S. It is a heterocyclic compound containing a thieno[2,3-b]pyridine ring system with an amino group at the 3-position and a carboxylic acid group at the 2-position. 3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID is commonly used in pharmaceutical research and development as a building block for the synthesis of novel drugs and medicinal compounds. Its unique structure and properties make it a valuable intermediate in the production of various pharmaceuticals with potential therapeutic applications.

InChI:InChI=1/C10H10N2O2S/c1-4-3-5(2)12-9-6(4)7(11)8(15-9)10(13)14/h3H,11H2,1-2H3,(H,13,14)

Upstream product

• 54585-47-6 3-cyano-4,6-dimethyl-2-mercaptopyridine 
• 79-11-8 chloroacetic acid 
• 54585-47-6 4,6-Dimethyl-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 14237-71-9 2-chloro-4,6-dimethylnicotinonitrile 
• 52505-44-9 methyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate 
• 128257-06-7 2-(3-Cyano-4,6-dimethyl)pyridyl (ethoxycarbonyl)methyl sulfide 
• 52505-56-3 ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate 
• 55023-72-8 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid; potassium salt 

Downstream Products

• 115919-85-2 3-Amino-4,6-dimethyl-thieno<2,3-b>pyridin-2-carbonsaeure-4-nitro-phenylester 
• 1610591-86-0 3-amino-N-(2-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)ethyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 
• 1610591-88-2 3-amino-N-(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)butyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 
• 1610591-89-3 3-amino-N-(5-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)pentyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 
• 1610591-93-9 3-amino-N-(5-(4-(2,3-dichlorophenyl)piperazin-1-yl)pentyl)-4,6-dimethylthieno[2,3-b]pyridine-2-carboxamide 
• 58327-83-6 2-(4-chlorobenzylidene)-4,6-dimethyl-2,3-dihydrothieno[2,3-b]pyridin-3-one 
• 128918-11-6 3-Amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylic acid cyclohexylamide 
• 128918-28-5 3-Amino-4,6-dimethylthieno<2,3-b>pyridine-2-carbohydrazide 
• 72701-64-5 3-Amino-4,6-dimethyl-thieno<2,3-b>pyridin-2-carbonsaeureanilid 
• 55023-32-0 4,6-dimethylthieno[2,3-b]pyridine-3(2H)-one 
• 99504-81-1 3-(p-nitrobenzylideneamino)-2,7,9-trimethyl pyrido<3',2':4,5>thieno-<3,2-d>pyrimidin-4(3H)one 

Relevant articles and documents

CARBOXAMIDES AS UBIQUITIN-SPECIFIC PROTEASE INHIBITORS

The present disclosure relates to modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25, pharmaceutical compositions comprising the inhibitors, and methods of using the inhibitors. The modulators, such as inhibitors, of at least one pathway chosen from USP28 and USP25 can be useful in the treatment of cancers, among other ailments.

Synthesis of some new pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones and pyrido[3′,2′: 4,5]thieno[2,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives

2,3-Disubstituted-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4( 3H) -ones 8a-8c, 9a-9c were obtained by treatment of pyrido[3′,2′:4,5]thieno[3,2-d][1,3]oxazin-4(3H)-one derivative 3, 3-diacetylamino-thieno[2,3-b]pyridine derivative 5 and 3-ethoxymethyleneaminothieno[2,3-b]pyridine derivative 7a with appropriate amines, respectively. Condensation of compounds 8b, 9b with appropriate α-chlorocarbonyl compounds gave the corresponding 3-substituted carbonylmethylene-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one derivatives 13a-d. 3-N-Substituted-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones 15a,b, 16a,b and 18a,b were also obtained by cyclization of carbohydrazide 14 with different reagents under a variety of conditions. On the other hand, cyclization of 3-amino-4-imino-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones 21a,b with appropriate orthoesters afforded the corresponding 3,5-dialkyl-pyrido[3′,2′:4,5]thieno[2,3-e]-1,2,4-triazolo[1,5-c] pyrimidines 22a-f.

Synthesis of 3 aminothieno [2,3 b]pyridine derivatives II

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