99504-81-1

Upstream product

• 144254-93-3 Sodium; 3-amino-4,6-dimethyl-thieno[2,3-b]pyridine-2-carboxylate 
• 72786-93-7 3-amino-2,7,9-trimetilpirido<3',2':4,5>tieno<3,2-d>pirimidin-4(3H)one 
• 555-16-8 4-nitrobenzaldehdye 
• 58327-76-7 3-amino-2-carboxylic acid-4,6-dimethylthieno[2,3-b]pyridine 
• 58327-87-0 2,7,9-trimethyl-4H-pyrido<3',2':4,5>thieno<3,2-d><1,3>-oxazin-4-one 
• 52505-56-3 ethyl 3-amino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate 
• 58327-91-6 ethyl 3-diacetylamino-4,6-dimethylthieno[2,3-b]pyridine-2-carboxylate 

Relevant academic research and scientific papers

Synthesis of some new pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones and pyrido[3′,2′: 4,5]thieno[2,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives

2,3-Disubstituted-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4( 3H) -ones 8a-8c, 9a-9c were obtained by treatment of pyrido[3′,2′:4,5]thieno[3,2-d][1,3]oxazin-4(3H)-one derivative 3, 3-diacetylamino-thieno[2,3-b]pyridine derivative 5 and 3-ethoxymethyleneaminothieno[2,3-b]pyridine derivative 7a with appropriate amines, respectively. Condensation of compounds 8b, 9b with appropriate α-chlorocarbonyl compounds gave the corresponding 3-substituted carbonylmethylene-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one derivatives 13a-d. 3-N-Substituted-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones 15a,b, 16a,b and 18a,b were also obtained by cyclization of carbohydrazide 14 with different reagents under a variety of conditions. On the other hand, cyclization of 3-amino-4-imino-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-ones 21a,b with appropriate orthoesters afforded the corresponding 3,5-dialkyl-pyrido[3′,2′:4,5]thieno[2,3-e]-1,2,4-triazolo[1,5-c] pyrimidines 22a-f.

SOME REACTIONS OF 3-AMINO-2-CARBOETHOXY-4,6-DIMETHYLTHIENOPYRIDINE. SYNTHESIS OF SOME NEW THIENOPYRIDINOPYRIMIDINES

Thienopyridine oxazinone (1) has been prepared and explored as a precursor by its reaction with some reagents namely, ammonium acetate, aliphatic amines, aromatic amines, hydrazine hydrate, thiosemicarbazide, and ethyl glycinate to give pyridothienopyrimidines (II-VII).The pyrimidinone compound (II) was converted to the 4-chloro derivative (X) by its reaction with excess POCl3.Interaction of the 4-chlorocompound (X) with some reagents namely, hydrazine hydrate, methyl amine, aniline, sodium thiophenolate, ethyl glycinate, thiosemicarbazide and thiourea, yielded pyridothieno-pyrimidine derivatives (XI-XVII) substituted at 4-position, respectively.