58328-99-7

Upstream product

• 34737-89-8 1-Benzyl-3-methyl-4-piperidon 
• 62-53-3 aniline 

Downstream Products

• 58329-00-3 1-benzyl-3-methyl-N-phenyl-4-piperidinamine 
• 42045-85-2 N-((3S,4R)-1-Benzyl-3-methyl-piperidin-4-yl)-N-phenyl-propionamide; hydrochloride 
• 42045-85-2 N-((3R,4R)-1-Benzyl-3-methyl-piperidin-4-yl)-N-phenyl-propionamide; hydrochloride 
• 97220-08-1 cis-N-(3-methyl-1-<2-(1,2,3,4-tetrahydro)naphthyl>-4-piperidinyl)-N-phenylpropanamide 
• 97220-08-1 trans-N-(3-methyl-1-<2-(1,2,3,4-tetrahydro)naphthyl>-4-piperidinyl)-N-phenylpropanamide 
• 42045-84-1 cis-N-<3-methyl-1-(phenylmethyl)-4-piperidinyl>-N-phenylpropanamide 
• 42045-84-1 trans-N-<3-methyl-1-(phenylmethyl)-4-piperidinyl>-N-phenylpropanamide 
• 33794-42-2 cis-N-<3-methyl-4-piperidinyl>-N-phenylpropanamide 
• 33794-42-2 trans-N-<3-methyl-4-piperidinyl>-N-phenylpropanamide 
• 101345-47-5 Furan-2-carboxylic acid {(3S,4R)-1-[2-(4-ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-phenyl-amide 
• 101344-74-5 N-{(3S,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-phenyl-propionamide 
• 101344-74-5 N-{(3R,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-phenyl-propionamide 
• 101344-76-7 N-{(3S,4R)-1-[2-(4-Ethyl-5-oxo-4,5-dihydro-tetrazol-1-yl)-ethyl]-3-methyl-piperidin-4-yl}-2-methoxy-N-phenyl-acetamide 
• 101344-42-7 Furan-2-carboxylic acid [(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-phenyl-amide 

Relevant academic research and scientific papers

Synthesis and Pharmacological Evaluation of a Series of New 3-Methyl-1,4-disubstituted-piperidine Analgesics

The synthesis and intravenous analgesic activity of a series of 3-methyl-4-(N-phenyl amido)piperidines, entries 34-79, is described.The methoxyacetamide pharmacophore produced a series of compounds with optimal analgesic potency and short duration of action. cis-42 was 13 036 times more potent than morphine and 29 times more potent than fentanyl; however, the corresponding diastereomer 43 was only 2778 and 6 times more potent, respectively.Compounds 40, 43, 47, and 57 are extremely short acting; all had durations of action of about 2 min, which was about 1/5 of that of fentanyl in the mouse hot-plate test at a dose equivalent to 2 times the ED50 analgesic dose.Among the many compounds that displayed exceptional analgesic activity, duration of action was one of the main factors for choosing a candidate for further pharmacological investigation.At present, cis-1--3-methyl-4-2-fluorophenyl)methoxyacetamido>piperidine hydrochloride (40) (Anaquest, A-3331.HCl, Brifentanil) is in clinical evaluation.Opiate analgesics that possess short duration of action are excellent candidates for short surgical procedures in an outpatient setting where a rapid recovery is required.

Fentanyl analogues 3. 2-(1,2,3,4-tetrahydro)-naphthyl substituted 4-anilidopiperidines

The synthesis and analgetic properties of 2-(1,2,3,4-tetrahydro)-naphthyl analogues of fentanyl and 3-methylfentanyl are reported. The relation of the N-phenethyl group to the piperidine ring is discussed.