58329-50-3Relevant academic research and scientific papers
Phosphane-mediated domino synthesis of tetrasubstituted furans from simple terminal activated olefins
Wang, Jianfang,Zhou, Rong,He, Zhengjie,He, Zheng-Rong
, p. 6033 - 6041,9 (2012)
Convenient and highly efficient syntheses of tetrasubstituted furans with flexible substituent patterns from simple and readily available starting materials have been developed. Under very mild conditions, with the mediation of stoichiometric nBu3P, simple terminal activated olefins and acyl chlorides or anhydrides smoothly furnish tetrasubstituted furans in modest to excellent yields. This synthetic strategy features a flexible selection of substituent pattern and a C-acylation/O-acylation/C-acylation/intramolecular Wittig reaction multiple domino assembly sequence. Simplicity can give rise to flexibility and efficiency. Convenient and highly efficient syntheses of tetrasubstituted furans from simple terminal activated olefins through phosphane-mediated multiple domino assembly sequences (such as C-acylation/O-acylation/C-acylation/intramolecular Wittig reaction) have been achieved.
Convergent synthesis of polysubstituted furans via catalytic phosphine mediated multicomponent reactions
Fan, Xia,Chen, Rongshun,Han, Jie,He, Zhengjie
, (2019/12/25)
Tri- or tetrasubstituted furans have been prepared from terminal activated olefins and acyl chlorides or anhydrides by a multicomponental convergent synthesis mode. Instead of stoichiometric nBu3P, only catalytic nBu3P or nBu3P=O is needed to furnish the furans in modest to excellent yields with a good functional group tolerance under the aid of reducing agent silane. This synthetic method features a silane-driven catalytic intramolecular Wittig reaction as a key annulation step and represents the first successful application of catalytic Wittig reaction in multicomponent cascade reaction.
