58332-29-9

Upstream product

• 32771-70-3 N-(4-nitro-benzoyl)-L-tyrosine ethyl ester 
• 60-18-4 L-tyrosine 
• 122-04-3 4-nitro-benzoyl chloride 
• 1080-06-4 L-Tyr-OMe 
• 1627753-24-5 C₁₇H₁₆N₂O₆ 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 934221-18-8 N-(N-5''-nitrobenzoyl-L-tyrosyl)-L-phenylalanine methyl ester 
• 7068-76-0 N-(4-amino-benzoyl)-L-tyrosine 

Relevant academic research and scientific papers

Synthesis and aldose reductase inhibitory activity of benzoyl-amino acid derivatives

A series of N-(4-methoxy, 4-fluoro, 4-trifluoromethyl and 4-nitrobenzoyl)-L-amino acids was synthesized and their inhibitory activity towards bovine lens aldose reductase (ALR2) was tested.

Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives

A series of Matijin-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l- phenylalanol) derivatives was synthesized and evaluated for their anti-tumor activities in hepatocellular carcinoma cells. The IC50 of compounds 1, 3, 4, 11, 13 were less than 20 μM, and compound 1 and 3 showed an IC 50 value of less than 9 μM. Expansion inhibition could be found significantly in compound 1 and 3-treated human hepatoma cell HepG2 and PLC/PRF/5, while both compounds exhibit lower toxicity to human hepatocyte cell line L-02. Compound 1 and 3 could induce cell cycle arrest at G1/S phase. This may be attributed to increase level of intracellular reactive oxygen species (ROS). Up-regulation of p38 MAPK activity in responding the ROS stabilize p53 and activate p21 transcription, the critical regulatory in G1/S checkpoint. Observations in this study shed light on the potential of MTS derivatives compound 1 and 3 as novel suppressors to human liver cancer.