58333-72-5

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 5-phenylthiazole-2-carboxylate is used as a building block for the development of new drugs due to its various biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. Its unique chemical structure and versatile applications make it a promising candidate for creating innovative pharmaceuticals.
Used in Agrochemical Industry:
Ethyl 5-phenylthiazole-2-carboxylate is used as a potential pesticide and herbicide in the agricultural sector. Its ability to inhibit various enzymes involved in plant and microbial growth makes it a valuable tool for controlling pests and weeds, thereby enhancing crop productivity and protecting agricultural resources.

InChI:InChI=1/C12H11NO2S/c1-2-15-12(14)11-13-8-10(16-11)9-6-4-3-5-7-9/h3-8H,2H2,1H3

Upstream product

• 84978-66-5 ethyl 2-oxo-2-((2-oxo-2-phenylethyl)amino)acetate 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 613-89-8 2-Aminoacetophenone 

Downstream Products

• 84978-62-1 5-phenyl-2-thiazolecarbohydrazide 
• 937369-77-2 5-phenyl-1,3-thiazole-2-carboxylic acid 
• 1314892-80-2 2-(bromomethyl)-5-phenylthiazole 
• 408330-56-3 (5-phenyl-1,3-thiazol-2-yl)methanol 
• 84978-64-3 2-phenyl-6-(5-phenyl-2-thiazolyl)-5H-thiazolo<3,2-a><1,3,5>triazine-5,7(6H)-dione 

Relevant academic research and scientific papers

FIVE-MEMBERED HETEROCYCLIC AMIDES WNT PATHWAY INHIBITOR

The present invention discloses a five-membered heterocyclic amide WNT pathway inhibitor, which belongs to a compound that regulates the activity of a Wnt signaling pathway, and provides a method for preparing such a compound, and the use of such a compound in preparing a medicament that antagonizes the Wnt signaling pathway. The five-membered heterocyclic amide WNT pathway inhibitor provided by the invention has a remarkable anti-tumor activity based on a target-based rational drug design of, and can be used for the development of a new generation of Wnt pathway inhibitors, and has a great clinical application value and considerable market potential.

URIDINE NUCLEOSIDE DERIVATIVES, COMPOSITIONS AND METHODS OF USE

This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to compounds, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma and inflammatory conditions.

COMPOUNDS AND METHODS for the inhibition of HDAC

Disclosed are compounds having the formula: wherein X1, X2, X3, R1, R2, R3, R4, Y, A, Z, L and n are as defined herein, and methods of making and using the same.

Pyrolysis of Benzyl 2-Oxazolecarbamates and Benzyl 4-Alkylallophanates

The pyrolysis of benzyl 2-oxazolecarbamates (I) and benzyl 4-alkylallophanates (II) was investigated.Heating of benzyl 5-phenyl-2-oxazolecarbamate (Ia) at 230 deg C gave benzyl alcohol and 2-phenyl-6-(5-phenyl-2-oxazolyl)-5H-oxazolotriazine-5,7(6H)-dione (IIIa).Compound IIIa was also obtained by heating the azide prepared from 5-phenyl-2-oxazolecarbohydrazide (IVa).In the same way, 2-methyl-6-(5-methyl-2-oxazolyl)-5H-oxazolotriazine-5,7(6H)-dione (IIIb) and 2-phenyl-6-(5-phenyl-2-thiazolyl)-5H-thiazolotriazine-5,7(6H)-dione (IIIc) were obtained from the corresponding hydrazides (IVb and IVc).Next, heating of benzyl 4-(2-phenylethyl)-allophanate (IIa) at 230 deg C gave cyanuric acid (VII), benzyl (2-phenylethyl)carbamate (VIII) and 1,3-bis(2-phenylethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (IX).Keywords - benzyl 2-oxazolecarbamate; benzyl 4-alkylallophanate; pyrolysis; 5H-oxazolotriazine-5,7(6H)-dione; 5H-thiazolotriazine-5,7(6H)-dione; ethyl 2-thiazolecarboxilate