58334-08-0

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
Ethyl 5-methylthiazole-2-carboxylate is utilized as a key intermediate in the synthesis of pharmaceuticals and agrochemicals. Its unique chemical structure and potential biological activities make it a valuable component in the development of new drugs and pesticides.
Used in Flavoring Agent Applications:
In the food industry, Ethyl 5-methylthiazole-2-carboxylate is employed as a flavoring agent. It imparts a savory and meaty taste to various products, enhancing their flavor profiles and consumer appeal.
Used in Chemistry Research:
Ethyl 5-methylthiazole-2-carboxylate is also used in chemistry research for studying its chemical properties and potential applications in various chemical reactions and processes.

Upstream product

• 19967-57-8 bromo-2 propanal 
• 16982-21-1 ethyl 2-amino-2-thioxoacetate 
• 123-38-6 propionaldehyde 
• 61291-21-2 5-methyl-1,3-thiazole-2-carboxylic acid 
• 75-03-6 ethyl iodide 

Downstream Products

• 61291-21-2 5-methyl-1,3-thiazole-2-carboxylic acid 
• 858486-43-8 5-methylthiazole-2-carbohydrazide 
• 99979-94-9 5-methyl-thiazole-2-carboxylic acid amide 
• 960235-24-9 ethyl 5-(bromomethyl)thiazole-2-carboxylate 
• 859487-10-8 (5-methyl-thiazol-2-yl)-diphenyl-methanol 
• 117887-04-4 5-methyl-thiazole-2-carbothioic acid amide 
• 100516-71-0 5-methyl-thiazole-2-carbonitrile 
• 79247-98-6 5-Methyl-thiazole-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

MRGPRX2 ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present disclosure is directed to use of MrgprX2 antagonists in the treatment of inflammatory disorders, e.g., inflammatory disorders of the skin. This invention is also directed to pharmaceutical compositions comprising a MrgprX2 antagonist and a pha

AZOLE AND THIAZOLE DERIVATIVES AND THEIR USE

Compounds of formula (I) are useful in the treatment of diseases where enhanced M3 receptor activation is implicated, such as respiritory tract diseases: wherein (i) R1 is C1-C6-alkyl or hydrogen; and R2 is hydrogen or a group -R7, -Z-Y-R7, -Z-NR9R10; -Z-CO-NR9R10, -Z-NR9-[AE11]C(O)O-R7, or -Z-C(O)-R7; and R3 is a lone pair, or C1C6-alkyl; or (ii) R1 and R3 together with the nitrogen to which they are attached form a heterocycloalkyl ring, and R2 is a lone pair or a group -R7, -Z-Y-R7, -Z-NR9R10, -Z-CO-NR9R10, -Z-NR9-[AE12]C(O)O-R7; or; -Z-C(O)-R7; or (iii) R1 and R2 together with the nitrogen to which they are attached form a heterocycloalkyl ring, said ring being substituted by a group -Y-R7, -Z-Y-R7, -Z-NR9R10; -Z-CO-NR9R10; -Z-NR9-[AE13]C(O)O-R7; or; -Z-C(O)-R7; and R3 is a lone pair, or C1-C6-aIkyl; R4 and R5 are independently selected from the group consisting of aryl, arytfused-heterocycloalkyl, heteroaryl, C1-C6-alkyl, cycloalkyl; R6 is -OH, C1-C6-alkyl, C1-C6-alkoxy, hydroxy-C1-C6-alkyl, nitrile, a group CONR82 or a hydrogen atom; A is an oxygen or a sulfur atom; X is an alkylene, alkenylene or alkynylene group; R7 is an C1-C6-alkyl, aryl, aryl-fused-cycloalkyl, aryl-ffused-heterocycloalkyl, heteroaryl, aryl(C1-C8-alkyl)-, heteroaryl(C1-C8-alkyl)-, cycloalkyl or heterocycloalkyl group; R8 is C1-C6-alkyl or a hydrogen atom; Z is a C1-C16-alkylene, C2-C16-alkenylene or C2-C16-alkynylene group; Y is a bond or oxygen atom; R9 and R10 are independently a hydrogen atom, C1-C6-alkyl, aryl, aryl-fused-heterocycloalkyl, aryl-fused-cycloalkyl, heteroaryl, aryl(C1-C6-alkyl)-, or heteroaryl(C1-C6-alkyl)- group; or R9 and R10 together with the nitrogen atom to which they are attached form a heterocyclic ring of 48 atoms, optionally containing a further nitrogen or oxygen atom.

An Infrared Study of Rotational Isomerism in Thiazole-2-carboxylates

A series of alkyl thiazole-2-carboxylates containing a range of substituents at the 4- and 5-positions has been prepared.Solutions of these esters (mostly new compounds) show well resolved doublets in the i.r.C=O region which arise from rotational isomers.The higher wavenumber components are assigned to the more polar carbonyl O,S-anti-s-trans-rotamers and the lower wavenumber components to the carbonyl O,S-syn-s-trans-forms.Small, but systematic, differences between the methyl esters are noted.