58349-17-0 Usage
Uses
Used in Pharmaceutical Industry:
(S)-2-Amino-5-methoxytetralin Hydrochloride is used as an intermediate in the synthesis of Rotigotine, a non-ergot dopamine agonist drug. It is utilized for the treatment of Parkinson's disease, a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the brain. Rotigotine helps alleviate the symptoms of Parkinson's disease by stimulating the dopamine receptors and improving motor function.
Additionally, due to its role as an intermediate in the synthesis of Rotigotine, (S)-2-Amino-5-methoxytetralin Hydrochloride may also contribute to the development of other pharmaceuticals that target the dopaminergic system for the treatment of various neurological and psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 58349-17-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,8,3,4 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 58349-17:
(7*5)+(6*8)+(5*3)+(4*4)+(3*9)+(2*1)+(1*7)=150
150 % 10 = 0
So 58349-17-0 is a valid CAS Registry Number.
InChI:InChI=1/C11H15NO.ClH/c1-13-11-4-2-3-8-7-9(12)5-6-10(8)11;/h2-4,9H,5-7,12H2,1H3;1H/t9-;/m0./s1
58349-17-0Relevant academic research and scientific papers
Oeztaskin, Necla,Goeksu, Sueleyman,Hasan Secen
, p. 2017 - 2024 (2011)
5-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine was synthesized from 2-naphthoic acid in six steps with an overall yield of 27%. Following the reaction sequence, bromination, esterification, substitution with NaOMe in the presence of CuI, the Birch reducti
α-Adrenergic Agents. 2. Synthesis and α1-Agonist Activity of 2-Aminotetralins
DeMarinis, R. M.,Shah, D. H.,Hall, R. F.,Hieble, J. P.,Pendleton, R. G.
, p. 136 - 141 (2007/10/02)
Substituted 2-aminotetralins are potent, selective, direct-acting agonists as postjunctional α1 receptors.Within this series, substituent alterations on the ring, as well as on the nitrogen, change the potency of compounds by over three orders
