58373-46-9

Upstream product

• 7440-44-0 pyrographite 
• 101601-80-3 3-amino-2-phenylpyridine 
• 7440-06-4 platinum 

Downstream Products

• 556824-87-4 (+/-)-(2R₃R,2S₃S)-1-(tert-Butoxycarbonyl)-2-phenylpiperidin-3-amine 
• 168398-02-5 (2-Methoxy-5-tetrazol-1-yl-benzyl)-(cis-2-phenyl-piperidin-3-yl)-amine dihydrochloride 

Relevant academic research and scientific papers

Bifunctional-thiourea-catalyzed diastereo- And enantioselective Aza-Henry reaction

Bifunctional thiourea 1a catalyzes aza-Henry reaction of nitroalkanes with N-Boc-imines to give syn-β-nitroamines with good to high diastereo- and enantioselectivity. Apart from the catalyst, the reaction requires no additional reagents such as a Lewis acid or a Lewis base. The N-protecting groups of the imines have a determining effect on the chirality of the prod ucts, that is, the reaction of N-Bocimines gives R adducts as major products, whereas the same reaction of N-phosphonoylimines furnishes the corresponding S adducts. Various types of nitroalkanes bearing aryl, alcohol, ether, and ester groups can be used as nucleophiles, providing access to a wide range of useful chiral building blocks in good yield and high enantiomeric excess. Synthetic versatility of the addition products is demonstrated by the transformation to chiral piperidine derivatives such as CP-99,994.

SYNTHESIS OF ARYL-SUBSTITUTED PIPERIDINES BY HYDROGENATION OF ARYL-SUBSTITUTED PYRIDINES

The invention is a process to hydrogenate an aryl-substituted pyridine, such as 2-phenyl-3-aminopyridine, without over-reducing the aryl ring using a specific Pt/C catalyst.

Method for producing optical-active cis-piperidine derivatives

An optical-active cis-piperidine derivative of high chemical purity and high optical purity is efficiently produced through optical resolution of a cis-piperidine derivative mixture, racemic cis-piperidine derivative with an optical-active tartaric acid d

5-PHENYLBENZYLAMINE COMPOUNDS, PROCESS FOR THEIR PRODUCTION AND INTERMEDIATES FOR THEIR SYNTHESIS

The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]: wherein Ring A represents a phenyl group having a substituent(s), ???Ra, Rb1 and Rb2 each represent hydrogen atom, a halogen a

Pharmaceutical agents for the treatment of emesis

The present invention relates to a novel process for preparing and resolving 3-amino-2-phenylpiperidine and for synthesizing from the enantiomers of such compound certain pharmaceutically active substituted 2-phenyl-3-benzylaminopiperidines. The substitut