58377-44-9

Usage

Uses

Used in Insecticide Production:
Tert-butyl N-methoxycarbamate is used as a synthetic intermediate for the preparation of (pyridinylmethylamino)furanones, which are compounds with insecticidal properties. These insecticides are employed in the agricultural industry to control pests and protect crops from damage, thereby ensuring a stable food supply and reducing economic losses due to pest infestations. The use of N-Boc-O-methyl hydroxylamine in the synthesis of these insecticides highlights its importance in the development of effective pest control strategies.

Upstream product

• 36016-38-3 tert-Butyl N-hydroxycarbamate 
• 74-88-4 methyl iodide 
• 24424-99-5 di-tert-butyl dicarbonate 
• 593-56-6 N-methoxylamine hydrochloride 
• 75-65-0 tert-butyl alcohol 
• 1516-56-9 azidoformiate de methyle 

Downstream Products

• 58377-43-8 tert.-Butyl-N-p-tert-butylphenyl-methoxycarbamat 
• 76570-50-8 N-tert-butoxycarbonyl-N-phenyl-O-methylhydroxylamine 
• 1010101-27-5 N-Boc-N-(4-nitrophenyl)-O-methylhydroxylamine 
• 1010101-26-4 N-Boc-N-(4-fluorophenyl)-O-methylhydroxylamine 
• 1010101-32-2 N-Boc-N-(3-bromophenyl)-O-methylhydroxylamine 
• 1010101-30-0 N-Boc-N-(4-acetylphenyl)-O-methylhydroxylamine 
• 1010101-31-1 N-Boc-N-(4-methylphenyl)-O-methylhydroxylamine 
• 1010101-28-6 N-Boc-N-(4-methoxyphenyl)-O-methylhydroxylamine 
• 1010101-29-7 N-Boc-N-(4-cyanophenyl)-O-methylhydroxylamine 
• 1010101-33-3 N-Boc-N-(3-carboethoxyphenyl)-O-methylhydroxylamine 
• 1237528-56-1 5-methoxy-8,8-dimethyl-6-oxo-7-oxa-2,5-diazanonanoic acid phenylmethyl ester 

Relevant academic research and scientific papers

Asymmetric Phase-Transfer Catalytic aza-Michael Addition to Cyclic Enone: Highly Enantioselective and Diastereoselective Synthesis of Cyclic 1,3-Aminoalcohols

The highly enantioselective aza-Michael reaction of tert-butyl β-naphthylmethoxycarbamate to cyclic enones has been accomplished by using a new cinchona alkaloid derived C(9)-urea ammonium catalyst under phase-transfer catalysis conditions with up to 98% ee at 0 °C. The resulting aza-Michael adducts can be converted to versatile intermediates by selective deprotection and the cyclic 1,3-aminoalcohols by diastereoselective reduction with up to 32:1, which have been widely used as important pharmacophores in pharmaceutical development.

Lewis acid-mediated radical cyclization: Stereocontrol in cascade radical addition-cyclization-trapping reactions

An efficient approach for achieving radical cyclizations by using hydroxamate ester as a coordination tether with Lewis acid was studied. The chiral Lewis acid-mediated cascade radical addition-cyclization-trapping reaction proceeded smoothly with good en

MITOTIC KINESIN INHIBITORS AND METHODS OF USE THEREOF

This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment of various disorders.

Electrophilic Aromatic Substitution with N-Methoxy-N-acylnitrenium Ions Generated from N-Chloro-N-methoxyamides: Syntheses of Nitrogen Heterocyclic Compounds Bearing a N-Methoxyamide Group

N-Methoxy-N-acylnitrenium ions (II), generated by treatment of N-chloro-N-methoxyamides with silver carbonate in trifluoroacetic acid, react with arenes to give N-aryl-N-methoxyamides in good yields.In the case of the intramolecular cyclization of N-chloro-N-methoxy-2-phenylacetamides, the mode of cyclization is highly dependent on the nature of ortho or para substituent groups.Nitrenium ions II can primarily attack three positions (C-1, C-2, and C-6) of a phenyl ring.Normally II attack C-6.On the other hand, when the ortho position was occupied with a substituent group, II attacked both C-2 and C-6, in the former case followed by a 1,2-substituent migration, which was proved by a deuterium labeling experiment.Especially, when a methoxy group is substituted on ortho or para position, II attack C-1 due to the effect of the electron-releasing methoxy group to give spiro dienone compounds 39.A general discussion of the utility and mechanistic details of these reactions is presented.