58379-94-5

Upstream product

• 19578-92-8 1-(3,4-dimethoxyphenyl)-2-propanol 
• 100-46-9 benzylamine 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 37629-53-1 (E)-1,2-dimethoxy-4-(2-nitroprop-1-enyl)benzene 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 2980-03-2 benzylidene-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethyl]-amine 

Downstream Products

• 63437-46-7 4-{2-[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethylamino]-1-hydroxy-ethyl}-2-(2-hydroxy-ethoxy)-phenol 
• 749794-65-8 4-(2-{Benzyl-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethyl]-amino}-1-hydroxy-ethyl)-2-(2-hydroxy-ethoxy)-phenol 
• 120-26-3 2-(3,4-dimethoxyphenyl)-1-methylethylamine 
• 58379-89-8 α-Phenyl-N-(1-<3',4'-dimethoxyphenyl>prop-2-yl)-nitron 
• 763872-37-3 2-{Benzyl-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethyl]-amino}-1-[4-hydroxy-3-(2-hydroxy-ethoxy)-phenyl]-ethanone 

Relevant academic research and scientific papers

New series of N-substituted phenyl ketone oxime ethers: Synthesis and bovine β3-adrenergic agonistic activities

A series of ten novel phenyl ketone oxime ethers substituted on the terminal nitrogen by either 1,3 benzodioxole, alkyl, aralkyl or aryl moiety were synthesized and tested for their activity at bovine β3-adrenoceptors. The best compound, which was the benzodioxole dicarboxylate derivative, showed potent β3-adrenergic agonistic activities in Chinese hamster ovary cells expressing the bovine β3-adrenoceptors with Kact and Ki values better than compound CL 316,243 used as reference (14 ± 6 nM and 203 ± 71 nM, respectively). In this series three compounds showed an antagonistic activity. Structure-activity relationships in these ketone oxime ethers are discussed.

Optically active 1-phenyl-2-substituted propane derivatives and methods of producing the same

An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) STR1 wherein R1 and R2 represent a lower alkyl group, etc., or R1 and R2 may form together an alkylene group, etc.; R3, R4 and R5 represent a hydrogen atom, etc.; and X represents a hydroxyl group which may be protected with a protective group, or a halogen atom etc., can readily be produced (i) by permitting a microorganism belonging to the genus Torulaspora, the genus Candida, the genus Pichia or the like to act on a phenylacetone derivative and asymmetrically reducing the compound, or (ii) by sterically inverting an (R)-enantiomer. (R,R)-1-phenyl-2-[(2-phenyl-1-methylethyl)amino]ethanol derivative having a high optical purity can easily be obtained from the compound of the formula (I). The ethanol derivative is useful as an anti-obesity agent and the like.