120-26-3

Basic information

• Product Name: 3,4-dimethoxy-alpha-methylphenethylamine
• Synonyms: 3,4-dimethoxy-alpha-methylphenethylamine;3,4-dimethoxyamphetamine;3-(3,4-Dimethoxyphenyl)-2-propanamine;3,4-Dimethoxy-α-methylbenzeneethanamine;α-Methyl-3,4-dimethoxybenzeneethanamine;α-Methyl-3,4-dimethoxyphenethylamine;13078-75-6 (Hydrochloride);3,4-Dimethoxyphenylisopropylamine
• CAS NO: 120-26-3
• Molecular Formula: C₁₁H₁₇NO₂
• Molecular Weight: 195.25818
• EINECS: 204-383-7
• Mol File: 120-26-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 39-40 °C
• Boiling Point: 289°Cat760mmHg
• Flash Point: 139.8°C
• Appearance: /
• Density: 1.023g/cm³
• PKA: 9.78±0.10(Predicted)
• CAS DataBase Reference: 3,4-dimethoxy-alpha-methylphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dimethoxy-alpha-methylphenethylamine(120-26-3)
• EPA Substance Registry System: 3,4-dimethoxy-alpha-methylphenethylamine(120-26-3)

Safety Data

• Hazardous Substances Data: 120-26-3(Hazardous Substances Data)

Upstream product

• 623-26-7 terephthalonitrile 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 
• 121-33-5 vanillin 
• 122-47-4 1-(3,4-dimethoxyphenyl)-2-nitropropene 
• 97-53-0 4-allylguaiacol 
• 579-71-5 2-nitrostyrene 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 109-73-9 N-butylamine 
• 19578-92-8 1-(3,4-dimethoxyphenyl)-2-propanol 
• 79-24-3 Nitroethane 
• 53979-33-2 3-(3,4-dimethoxyphenyl)-2-methylpropanoic acid 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 91994-54-6 N-(trifluoroacetyl)-α-amino-3,4-dimethoxypropiophenone 
• 91-16-7 1,2-dimethoxybenzene 

Downstream Products

• 103266-52-0 1-(3,4-bis-benzyloxy-phenyl)-2-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamino]-ethanone 
• 65008-89-1 5-{3-[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethylamino]-2-hydroxy-propoxy}-8-(2-methoxy-ethoxy)-3,4-dihydro-1H-quinolin-2-one 
• 80090-11-5 8-Benzyloxy-5-{3-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethylamino]-2-hydroxy-propoxy}-3,4-dihydro-1H-quinolin-2-one 
• 91944-43-3 1-[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethylamino]-3-[4-(5-thiophen-2-yl-1H-imidazol-2-yl)-phenoxy]-propan-2-ol 
• 142893-52-5 1-(2-nitro-4,5-dimethoxyphenyl)-2-aminopropane 
• 58380-00-0 N-(1-methyl-2-(3,4-dimethoxy-phenyl)ethyl)hydroxylamine 
• 180698-55-9 2-Phthalimido-3-(3',4'-dimethoxyphenyl)propane 
• 62717-86-6 N-[2-(3,4-dimethoxyphenyl)-1-methylethyl]-2-hydroxy-2-phenylethylamine 
• 16359-24-3 T 13 
• 17279-41-3 (S)-2-amino-1-(3,4-dimethoxyphenyl)propane 
• 64778-78-5 (R)-3,4-dimethoxy-α-methylbenzeneethanamine 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 555-64-6 α-methyldopamine 
• 33236-61-2 1-(3,4-dimethoxyphenyl)-N-methylpropan-2-amine 

Relevant articles and documents

Transaminase-mediated synthesis of enantiopure drug-like 1-(3′,4′-disubstituted phenyl)propan-2-amines

Transaminases (TAs) offer an environmentally and economically attractive method for the direct synthesis of pharmaceutically relevant disubstituted 1-phenylpropan-2-amine derivatives starting from prochiral ketones. In this work, we report the application of immobilised whole-cell biocatalysts with (R)-transaminase activity for the synthesis of novel disubstituted 1-phenylpropan-2-amines. After optimisation of the asymmetric synthesis, the (R)-enantiomers could be produced with 88-89% conversion and >99% ee, while the (S)-enantiomers could be selectively obtained as the unreacted fraction of the corresponding racemic amines in kinetic resolution with >48% conversion and >95% ee. This journal is

Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.

Instantaneous SmI2/H2O/amine mediated reduction of nitroalkanes and α,β-unsaturated nitroalkenes

A rapid method for efficient reduction of nitroalkanes and α,β-unsaturated nitroalkenes using SmI2/H2O/amine has been developed.