5838-05-1

Usage

Uses

Used in Organic Synthesis:
(2Z)-N-(1,2-dihydroacenaphthylen-5-yl)-3-phenylprop-2-enamide is used as a building block or intermediate in organic synthesis for the development of new compounds with specific properties. Its unique molecular structure allows for various chemical reactions and modifications, facilitating the creation of novel organic molecules.
Used in Drug Discovery:
In the pharmaceutical industry, (2Z)-N-(1,2-dihydroacenaphthylen-5-yl)-3-phenylprop-2-enamide is used as a potential lead compound for drug discovery. Its specific molecular features may offer therapeutic benefits, and further research can help in optimizing its properties to target specific diseases or conditions.
Used in Material Science:
(2Z)-N-(1,2-dihydroacenaphthylen-5-yl)-3-phenylprop-2-enamide is utilized in material science for the development of new materials with unique properties. Its molecular structure may contribute to the creation of advanced materials for various applications, such as sensors, electronic devices, or other high-tech industries.

Upstream product

• 64-17-5 ethanol 
• 15664-29-6 pheophorbide-a 
• 603-17-8 pheophytin a 
• 39391-40-7 chlorophyll α 
• 15664-29-6 pheophorbide a 
• 5594-30-9 methylpheophorbide a 

Relevant academic research and scientific papers

METHOD OF PREPARING PURPURIN 18 FROM LIVE CHLORELLA

The present invention relates to a method for preparing purpurin 18 which is a photosensitizer (PS) useful for photodynamic therapy (PDT) and, more specifically, to a method for preparing purpurin 18, which comprises steps of: extracting chlorophyll alpha by using intact chlorella cells itself which is not broken; and obtaining a precursor material of purpurin 18 and methyl or ethyl pheophorbides from the extracts. According to the present invention, it is possible to produce purpurin 18 with at a high yield through a relatively simple process.(AA) Purpurin18 manufacturing process1(BB) Chlorella(CC) Chlorophyll a/li>(DD) Methyl pheophorbide a/li>(EE) Purpurin 18(FF) Purpurin 18 precursorCOPYRIGHT KIPO 2016

Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents.

A methanolic crude extract of the plant Garuga pinnata Roxb. (Burseraceae) showed promising cytotoxic activity against a panel of human tumor cell lines in vitro, including KB and its drug-resistant sublines (Ferguson et al. Cancer Res. 1988, 48, 5956). Pheophorbide-a and-b methyl esters (3,4) were isolated as active principles with broad photo-dependent cytotoxic activities in the micromolar range. These findings prompted SAR studies of known and novel pheophorbide-a derivatives as photo-dependent and photo-independent cytotoxic agents. The results showed that zinc-protoporphyrin IX (10), zinc 13(R)-hydroxypheophorbide-a methyl ester (22), and zinc chlorin-e6 trimethyl ester (13) possessed photo-independent cytotoxic activity. Compounds 13 and 22 were the most active cytotoxic agents of the series (mean ED(50) 4.6 +/- 1.0 microM and 5.7 +/- 0.7 microM, respectively) against KB cells incubated in the dark.

Transesterification of the α-keto ester in methyl pheophorbide-a

Transesterification of the α-keto methyl ester in methyl pheophorbide- a proceeds smoothly under neutral conditions, allowing the preparation of a variety of models such as steroid-pheophorbide, pyromellitimide-pheophorbide, thymidine-pheophorbide, pheoph