583880-92-6Relevant academic research and scientific papers
A new method using 1,3,5-triazine as an umpolung hydrogen cyanide equivalent toward the syntheses of isoquinolinone and 2-pyridone derivatives
Hayashida, Joji,Yoshida, Shinya
supporting information, p. 3876 - 3879 (2018/10/02)
An investigation of Hermecz and Hartenstein's cyclization methods was conducted. Overcoming the limited substrate scope allowed the expansion of the synthetic application of 1,3,5-triazine as an umpolung hydrogen cyanide equivalent. The reaction proceeded under mild conditions to provide various isoquinolinone and 2-pyridone derivatives with excellent yields.
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H 1 antagonists. Part II: Optimising in vivo clearance
Furber, Mark,Alcaraz, Lilian,Luckhurst, Christopher,Bahl, Ash,Beaton, Haydn,Bowers, Keith,Collington, John,Denton, Rebecca,Donald, David,Kinchin, Elizabeth,MacDonald, Cathy,Rigby, Aaron,Riley, Rob,Soars, Matt,Springthorpe, Brian,Webborn, Peter
, p. 7707 - 7710 (2013/02/21)
The second part of this communication focuses on the resolution of issues surrounding the series of hydroxyamide phenoxypiperidine CCR3/H1 dual antagonists described in Part I. This involved further structural exploration directed at reducing m
